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Peter van Ulsen

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Recent Articles
1.
Huynh D, Nolfi E, Guleed S, Medfai L, Wolf N, Uijen R, et al.
Biomed Pharmacother . 2024 Oct; 180:117563. PMID: 39405914
Chlamydia trachomatis causes the most prevalent bacterial sexually transmitted infection worldwide. Its complex lifecycle and the lack of appropriate antigen delivery vehicles make it difficult to develop an effective C....
2.
Kes M, Wang B, van Ulsen P, Hamoen L, Luirink J
Microbiology (Reading) . 2024 Jun; 170(6). PMID: 38847798
is a Gram-positive bacterium that is frequently used in the bioindustry for the production of various proteins, because of its superior protein secretion capacities. To determine optimal conditions for protein...
3.
Habjan E, Schouten G, Speer A, van Ulsen P, Bitter W
FEMS Microbiol Rev . 2024 Apr; 48(3). PMID: 38684467
The rise of multidrug-resistant bacteria underlines the need for innovative treatments, yet the introduction of new drugs has stagnated despite numerous antimicrobial discoveries. A major hurdle is a poor correlation...
4.
Huynh D, Nolfi E, Medfai L, van Ulsen P, Jong W, Sijts A, et al.
Hum Vaccin Immunother . 2024 Mar; 20(1):2330768. PMID: 38517203
is an obligate intracellular pathogen responsible for the most prevalent bacterial sexually transmitted disease globally. The high prevalence of chlamydial infections underscores the urgent need for licensed and effective vaccines...
5.
Cleenewerk L, Luirink J, van Ulsen P
Methods Mol Biol . 2024 Mar; 2778:367-381. PMID: 38478289
Biogenesis of the outer membrane (OM) of Gram-negative bacteria involves two processes essential for growth, that is, the insertion of β-barrel outer membrane proteins (OMPs) by the Bam complex and...
6.
Huynh D, Jong W, Oudejans M, Berg van Saparoea H, Luirink J, van Ulsen P
Membranes (Basel) . 2023 Apr; 13(4). PMID: 37103793
is the bacterial pathogen that causes most cases of sexually transmitted diseases annually. To combat the global spread of asymptomatic infection, development of effective (mucosal) vaccines that offer both systemic...
7.
Le N, van Ulsen P, van Spanning R, Brouwer A, van Straalen N, Roelofs D
Genes (Basel) . 2022 Aug; 13(8). PMID: 36011312
Horizontal gene transfer (HGT) is defined as the acquisition by an organism of hereditary material from a phylogenetically unrelated organism. This process is mostly observed among bacteria and archaea, and...
8.
Paulussen F, Schouten G, Moertl C, Verheul J, Hoekstra I, Koningstein G, et al.
J Am Chem Soc . 2022 Aug; 144(33):15303-15313. PMID: 35945166
The use of antibiotics is threatened by the emergence and spread of multidrug-resistant strains of bacteria. Thus, there is a need to develop antibiotics that address new targets. In this...
9.
Huynh D, Jong W, Koningstein G, van Ulsen P, Luirink J
Int J Mol Sci . 2022 Jul; 23(13). PMID: 35806397
A licensed vaccine is not yet available. Recombinant major outer membrane protein (-MOMP), the most abundant constituent of the chlamydial outer membrane complex, is considered the most attractive candidate for...
10.
Schouten G, Paulussen F, Kuipers O, Bitter W, Grossmann T, van Ulsen P
Antibiotics (Basel) . 2022 Feb; 11(2). PMID: 35203875
The rising incidence of multidrug resistance in Gram-negative bacteria underlines the urgency for novel treatment options. One promising new approach is the synergistic combination of antibiotics with antimicrobial peptides. However,...