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Peter Tummino

Explore the profile of Peter Tummino including associated specialties, affiliations and a list of published articles. Areas
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Articles 6
Citations 814
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Recent Articles
1.
Leit S, Greenwood J, Carriero S, Mondal S, Abel R, Ashwell M, et al.
J Med Chem . 2023 Jul; 66(15):10473-10496. PMID: 37427891
TYK2 is a key mediator of IL12, IL23, and type I interferon signaling, and these cytokines have been implicated in the pathogenesis of multiple inflammatory and autoimmune diseases such as...
2.
Lercher L, Simon N, Bergmann A, Tauchert M, Bochmann D, Bashir T, et al.
SLAS Discov . 2022 May; 27(5):306-313. PMID: 35513262
The dysregulation of the PRC1/2 complex plays a key role in lineage plasticity in prostate cancer and may be required to maintain neuroendocrine phenotype. [1] CBX2, a key component of...
3.
Chaidos A, Caputo V, Gouvedenou K, Liu B, Marigo I, Chaudhry M, et al.
Blood . 2013 Dec; 123(5):697-705. PMID: 24335499
The bromodomain and extraterminal (BET) protein BRD2-4 inhibitors hold therapeutic promise in preclinical models of hematologic malignancies. However, translation of these data to molecules suitable for clinical development has yet...
4.
Yang J, Campobasso N, Biju M, Fisher K, Pan X, Cottom J, et al.
Chem Biol . 2011 Feb; 18(2):177-86. PMID: 21338916
c-Abl kinase activity is regulated by a unique mechanism involving the formation of an autoinhibited conformation in which the N-terminal myristoyl group binds intramolecularly to the myristoyl binding site on...
5.
Blackburn C, Guan B, Brown J, Cullis C, Condon S, Jenkins T, et al.
Bioorg Med Chem Lett . 2006 Apr; 16(13):3504-9. PMID: 16644217
Several potent, cell permeable 4-aryl-dihydropyrimidinones have been identified as inhibitors of FATP4. Lipophilic ester substituents at the 5-position and substitution at the para-position (optimal groups being -NO(2) and CF(3)) of...
6.
Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, et al.
J Biol Chem . 2002 Jan; 277(17):14838-43. PMID: 11815627
Human angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a zinc metalloprotease whose closest homolog is angiotensin I-converting enzyme. To begin to elucidate the physiological role of ACE2, ACE2 was purified, and its...