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Peter Ruth

Explore the profile of Peter Ruth including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 147
Citations 3287
Followers 0
Related Specialties
Biochemistry
Physiology
Neurology
Top 10 Co-Authors
Robert Lukowski
Matthias Sausbier
Michael J Shipston
Marlies Knipper
Ulrike Sausbier
Achim Schmidtko
Stephan M Huber
Ulrike Zimmermann
Lukas Ruttiger
Heather McClafferty
Published In
J Biol Chem
J Neurosci
FASEB J
PLoS One
Proc Natl Acad Sci U S A
Affiliations
Soon will be listed here.
Recent Articles
1.
Slack potassium channels in spinal dorsal horn neurons control neuropathic pain and acute itch
Zhou F, Engel P, Ruth P, Lukowski R, Schmidtko A, Lu R
Pain . 2024 Oct; PMID: 39382315
The sodium-activated potassium channel Slack (KNa1.1, Kcnt1) plays a critical role in tuning neuronal excitability. Previous studies have revealed that Slack is expressed in neurons of the superficial dorsal horn...
2.
Slack K+ channels confer protection against myocardial ischemia/reperfusion injury
Roslan A, Paulus K, Yang J, Matt L, Bischof H, Langst N, et al.
Cardiovasc Res . 2024 Aug; PMID: 39102831
Aims: Na+-activated Slack potassium (K+) channels are increasingly recognized as regulators of neuronal activity, yet little is known about their role in the cardiovascular system. Slack activity increases when intracellular...
3.
K channel targeting impairs DNA repair and invasiveness of patient-derived glioblastoma stem cells in culture and orthotopic mouse xenografts which only in part is predictable by K expression levels
Ganser K, Stransky N, Abed T, Quintanilla-Martinez L, Gonzalez-Menendez I, Naumann U, et al.
Int J Cancer . 2024 Jun; 155(10):1886-1901. PMID: 38938062
Prognosis of glioblastoma patients is still poor despite multimodal therapy. The highly brain-infiltrating growth in concert with a pronounced therapy resistance particularly of mesenchymal glioblastoma stem-like cells (GSCs) has been...
4.
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch
Balzulat A, Zhu W, Flauaus C, Hernandez-Olmos V, Heering J, Sethumadhavan S, et al.
Adv Sci (Weinh) . 2024 Feb; 11(15):e2307237. PMID: 38350720
Various disorders are accompanied by histamine-independent itching, which is often resistant to the currently available therapies. Here, it is reported that the pharmacological activation of Slack (Kcnt1, K1.1), a potassium...
5.
Efficacy of combined tumor irradiation and K3.1-targeting with TRAM-34 in a syngeneic glioma mouse model
Stransky N, Ganser K, Quintanilla-Martinez L, Gonzalez-Menendez I, Naumann U, Eckert F, et al.
Sci Rep . 2023 Nov; 13(1):20604. PMID: 37996600
The intermediate-conductance calcium-activated potassium channel K3.1 has been proposed to be a new potential target for glioblastoma treatment. This study analyzed the effect of combined irradiation and K3.1-targeting with TRAM-34...
6.
BK channels sustain neuronal Ca oscillations to support hippocampal long-term potentiation and memory formation
Pham T, Hussein T, Calis D, Bischof H, Skrabak D, Cruz Santos M, et al.
Cell Mol Life Sci . 2023 Nov; 80(12):369. PMID: 37989805
Mutations of large conductance Ca- and voltage-activated K channels (BK) are associated with cognitive impairment. Here we report that CA1 pyramidal neuron-specific conditional BK knock-out (cKO) mice display normal locomotor...
7.
Slack K channels limit kainic acid-induced seizure severity in mice by modulating neuronal excitability and firing
Skrabak D, Bischof H, Pham T, Ruth P, Ehinger R, Matt L, et al.
Commun Biol . 2023 Oct; 6(1):1029. PMID: 37821582
Mutations of the Na-activated K channel Slack (KCNT1) are associated with terrible epilepsy syndromes that already begin in infancy. Here we report increased severity of acute kainic acid-induced seizures in...
8.
Acute deletion of the central MR/GR steroid receptor correlates with changes in LTP, auditory neural gain, and GC-A cGMP signaling
Calis D, Hess M, Marchetta P, Singer W, Modro J, Nelissen E, et al.
Front Mol Neurosci . 2023 Mar; 16:1017761. PMID: 36873102
The complex mechanism by which stress can affect sensory processes such as hearing is still poorly understood. In a previous study, the mineralocorticoid (MR) and/or glucocorticoid receptor (GR) were deleted...
9.
Tumoricidal, Temozolomide- and Radiation-Sensitizing Effects of K3.1 K Channel Targeting In Vitro Are Dependent on Glioma Cell Line and Stem Cell Fraction
Stransky N, Ganser K, Naumann U, M Huber S, Ruth P
Cancers (Basel) . 2022 Dec; 14(24). PMID: 36551685
Reportedly, the intermediate-conductance Ca-activated potassium channel K3.1 contributes to the invasion of glioma cells into healthy brain tissue and resistance to temozolomide and ionizing radiation. Therefore, K3.1 has been proposed...
10.
IK channels control breast cancer metabolism including AMPK-driven autophagy
Gross D, Bischof H, Maier S, Sporbeck K, Birkenfeld A, Malli R, et al.
Cell Death Dis . 2022 Oct; 13(10):902. PMID: 36302750
Ca-activated K channels of intermediate conductance (IK) are frequently overexpressed in breast cancer (BC) cells, while IK channel depletion reduces BC cell proliferation and tumorigenesis. This raises the question, of...