Achim Schmidtko
Overview
Explore the profile of Achim Schmidtko including associated specialties, affiliations and a list of published articles.
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70
Citations
1185
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Recent Articles
1.
Hernandez-Olmos V, Heering J, Ildefeld N, Ehrler J, Kaps A, Rajkumar R, et al.
J Med Chem
. 2025 Jan;
68(2):1195-1221.
PMID: 39803894
The leukotriene B4 receptor 2 (BLT2) is a G-protein coupled receptor, which is endogenously activated by 12()-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT). BLT2 is gaining attention as a potential therapeutic target involved in...
2.
Engel P, Zhou F, Tran B, Schmidtko A, Lu R
Front Pharmacol
. 2025 Jan;
15:1459735.
PMID: 39744124
Heat sensation is mediated by specialized heat-sensitive neurons in the somatosensory system that innervates the skin. Previous studies revealed that noxious heat sensation is controlled by the sodium (Na)-activated potassium...
3.
Gross T, Stehle D, Nagel C, Zhou F, Duman E, Hernandez-Olmos V, et al.
Anesthesiology
. 2024 Nov;
142(2):332-348.
PMID: 39503623
Background: Emerging evidence indicates that cyclic nucleotide phosphodiesterases exert distinct functions in pain processing and that targeting phosphodiesterases might be a novel strategy for pain relief. This study hypothesized that...
4.
Zhou F, Engel P, Ruth P, Lukowski R, Schmidtko A, Lu R
Pain
. 2024 Oct;
PMID: 39382315
The sodium-activated potassium channel Slack (KNa1.1, Kcnt1) plays a critical role in tuning neuronal excitability. Previous studies have revealed that Slack is expressed in neurons of the superficial dorsal horn...
5.
Roslan A, Paulus K, Yang J, Matt L, Bischof H, Langst N, et al.
Cardiovasc Res
. 2024 Aug;
PMID: 39102831
Aims: Na+-activated Slack potassium (K+) channels are increasingly recognized as regulators of neuronal activity, yet little is known about their role in the cardiovascular system. Slack activity increases when intracellular...
6.
Burgers L, Ciurus S, Engel P, Kuntschar S, Raue R, Kiprina A, et al.
Biomed Pharmacother
. 2024 Jun;
176:116907.
PMID: 38865849
The plant alkaloid homoharringtonine (HHT) is a Food and Drug Administration (FDA)-approved drug for the treatment of hematologic malignancies. In addition to its well-established antitumor activity, accumulating evidence attributes anti-inflammatory...
7.
Balzulat A, Zhu W, Flauaus C, Hernandez-Olmos V, Heering J, Sethumadhavan S, et al.
Adv Sci (Weinh)
. 2024 Feb;
11(15):e2307237.
PMID: 38350720
Various disorders are accompanied by histamine-independent itching, which is often resistant to the currently available therapies. Here, it is reported that the pharmacological activation of Slack (Kcnt1, K1.1), a potassium...
8.
Aue A, Englert N, Harrer L, Schwiering F, Gaab A, Konig P, et al.
Respir Res
. 2023 Jun;
24(1):167.
PMID: 37349733
Background: The origin of αSMA-positive myofibroblasts, key players within organ fibrosis, is still not fully elucidated. Pericytes have been discussed as myofibroblast progenitors in several organs including the lung. Methods:...
9.
Friebe A, Kraehling J, Russwurm M, Sandner P, Schmidtko A
Naunyn Schmiedebergs Arch Pharmacol
. 2023 Apr;
396(8):1669-1686.
PMID: 37079081
Increasing cGMP is a unique therapeutic principle, and drugs inhibiting cGMP-degrading enzymes or stimulating cGMP production are approved for the treatment of various diseases such as erectile dysfunction, coronary artery...
10.
Kallenborn-Gerhardt W, Schroder K, Schmidtko A
Antioxidants (Basel)
. 2022 Jun;
11(6).
PMID: 35740059
Inflammation or injury to the somatosensory nervous system may result in chronic pain conditions, which affect millions of people and often cause major health problems. Emerging lines of evidence indicate...