Peter R Shepherd
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Explore the profile of Peter R Shepherd including associated specialties, affiliations and a list of published articles.
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110
Citations
2485
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Recent Articles
1.
Gong G, Masson G, Lee W, Dickson J, Kendall J, Rathinaswamy M, et al.
Biochem J
. 2024 Nov;
481(23):1787-1802.
PMID: 39485310
PI3Kα, consisting of the p110α isoform of the catalytic subunit of PI 3-kinase (encoded by PIK3CA) and the p85α regulatory subunit (encoded by PI3KR1) is activated by growth factor receptors....
2.
Oh J, Przepiorski A, Chang H, Dodd R, Sander V, Sorrenson B, et al.
J R Soc N Z
. 2024 Oct;
52(1):54-67.
PMID: 39440007
We aimed to generate human induced pluripotent stem cell (iPSC) lines from New Zealand donors. These lines are the first to be generated in New Zealand. Human dermal fibroblasts were...
3.
Wang Q, Leask M, Lee K, Jaiswal J, Kallingappa P, Dissanayake W, et al.
Diabetologia
. 2024 Oct;
68(3):537-548.
PMID: 39422716
Aims/hypothesis: Metformin is an important first-line treatment for type 2 diabetes and acts by increasing the body's ability to dispose of glucose. Metformin's efficacy can be affected by genetic variants...
4.
Wang Q, McCormick S, Leask M, Watson H, OSullivan C, Krebs J, et al.
Biosci Rep
. 2024 Jun;
44(7).
PMID: 38896441
Lipoprotein(a) (Lp(a)) is a low-density lipoprotein (LDL)-like particle in which the apolipoprotein B component is covalently linked to apolipoprotein(a) (apo(a)). Lp(a) is a well-established independent risk factor for cardiovascular diseases....
5.
Rizwan M, Kamstra K, Pretz D, Shepherd P, Tups A, Grattan D
J Neurosci
. 2024 Feb;
44(14).
PMID: 38395612
β-Catenin is a bifunctional molecule that is an effector of the wingless-related integration site (Wnt) signaling to control gene expression and contributes to the regulation of cytoskeleton and neurotransmitter vesicle...
6.
Puliuvea C, Immanuel T, Green T, Tsai P, Shepherd P, Kalev-Zylinska M
Hematology
. 2024 Jan;
29(1):2297597.
PMID: 38197452
Objectives: This study aimed to compile bioinformatic and experimental information for missense variants previously reported in myeloproliferative neoplasms (MPN) and determine if germline -I724T, recently found to be common in...
7.
Fernando S, Wang Q, Hay D, Bathgate R, Shepherd P, Lee K
Biosci Rep
. 2023 Mar;
43(4).
PMID: 36947541
RXFP4 is a G protein-coupled receptor (GPCR) in the relaxin family. It has recently been recognised that this receptor and its cognate ligand INSL5 may have a role in the...
8.
Masson S, Dissanayake W, Broome S, Hedges C, Peeters W, Gram M, et al.
Physiol Rep
. 2023 Feb;
11(4):e15536.
PMID: 36807886
A central characteristic of insulin resistance is the impaired ability for insulin to stimulate glucose uptake into skeletal muscle. While insulin resistance can occur distal to the canonical insulin receptor-PI3k-Akt...
9.
Brandon R, Jiang Y, Yeu R, Tweedie-Cullen R, Smallman K, Doherty G, et al.
Front Endocrinol (Lausanne)
. 2023 Jan;
13:1091421.
PMID: 36699039
Background: Understanding which group of patients with type 2 diabetes will have the most glucose lowering response to certain medications (which target different aspects of glucose metabolism) is the first...
10.
Tran K, Kolekar S, Wang Q, Shih J, Buchanan C, Deva S, et al.
Mol Cancer Ther
. 2022 Oct;
21(12):1777-1787.
PMID: 36198029
The fact that 10% of colorectal cancer tumors harbor BRAF V600E mutations suggested targeting BRAF as a potential therapy. However, BRAF inhibitors have only limited single-agent efficacy in this context....