Peter N Cockerill
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Explore the profile of Peter N Cockerill including associated specialties, affiliations and a list of published articles.
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62
Citations
1545
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Recent Articles
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2.
Coleman D, Keane P, Chin P, Ames L, Kellaway S, Blair H, et al.
iScience
. 2024 Apr;
27(4):109576.
PMID: 38638836
AML is characterized by mutations in genes associated with growth regulation such as internal tandem duplications (ITD) in the receptor kinase FLT3. Inhibitors targeting FLT3 (FLT3i) are being used to...
3.
Kellaway S, Potluri S, Keane P, Blair H, Ames L, Worker A, et al.
Nat Commun
. 2024 Feb;
15(1):1359.
PMID: 38355578
Acute Myeloid Leukemia (AML) is caused by multiple mutations which dysregulate growth and differentiation of myeloid cells. Cells adopt different gene regulatory networks specific to individual mutations, maintaining a rapidly...
4.
Potluri S, Kellaway S, Coleman D, Keane P, Imperato M, Assi S, et al.
Leukemia
. 2024 Jan;
38(2):403-407.
PMID: 38172329
No abstract available.
5.
Coleman D, Keane P, Luque-Martin R, Chin P, Blair H, Ames L, et al.
Cell Rep
. 2023 Dec;
42(12):113568.
PMID: 38104314
Acute myeloid leukemia (AML) is a heterogeneous disease caused by different mutations. Previously, we showed that each mutational subtype develops its specific gene regulatory network (GRN) with transcription factors interacting...
6.
Maytum A, Edginton-White B, Keane P, Cockerill P, Cazier J, Bonifer C
Life Sci Alliance
. 2023 Nov;
7(2).
PMID: 37989524
Tissue-specific gene regulation during development involves the interplay between transcription factors and epigenetic regulators binding to enhancer and promoter elements. The pattern of active enhancers defines the cellular differentiation state....
7.
Schleussner N, Cauchy P, Franke V, Giefing M, Fornes O, Vankadari N, et al.
Nat Commun
. 2023 Nov;
14(1):6947.
PMID: 37935654
Disease-causing mutations in genes encoding transcription factors (TFs) can affect TF interactions with their cognate DNA-binding motifs. Whether and how TF mutations impact upon the binding to TF composite elements...
8.
Coleman D, Keane P, Luque-Martin R, Chin P, Blair H, Ames L, et al.
bioRxiv
. 2023 Jul;
PMID: 37503022
AML is a heterogenous disease caused by different mutations. We have previously shown that each mutational sub-type develops its specific gene regulatory network (GRN) with transcription factors interacting with multiple...
9.
Adamo A, Chin P, Keane P, Assi S, Potluri S, Kellaway S, et al.
Leukemia
. 2022 Nov;
37(1):102-112.
PMID: 36333583
Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy caused by mutations in genes encoding transcriptional and epigenetic regulators together with signaling genes. It is characterized by a disturbance of...
10.
Tirtakusuma R, Szoltysek K, Milne P, Grinev V, Ptasinska A, Chin P, et al.
Blood
. 2022 Jul;
140(17):1875-1890.
PMID: 35839448
The fusion gene MLL/AF4 defines a high-risk subtype of pro-B acute lymphoblastic leukemia. Relapse can be associated with a lineage switch from acute lymphoblastic to acute myeloid leukemia, resulting in...