Peter N Cockerill
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Explore the profile of Peter N Cockerill including associated specialties, affiliations and a list of published articles.
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62
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1545
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Recent Articles
11.
Kellaway S, Coleman D, Cockerill P, Raghavan M, Bonifer C
Exp Hematol
. 2022 Mar;
111:1-12.
PMID: 35341804
The transcription factor RUNX1 is essential for correct hematopoietic development; in its absence in the germ line, blood stem cells are not formed. RUNX1 orchestrates dramatic changes in the chromatin...
12.
13.
Bevington S, Fiancette R, Gajdasik D, Keane P, Soley J, Willis C, et al.
Front Immunol
. 2021 Jun;
12:642807.
PMID: 34108962
T cell immunological memory is established within days of an infection, but little is known about the changes in gene regulatory networks accounting for their ability to respond more efficiently...
14.
Potluri S, Assi S, Chin P, Coleman D, Pickin A, Moriya S, et al.
Cell Rep
. 2021 Apr;
35(3):109010.
PMID: 33882316
Acute myeloid leukemia (AML) is caused by recurrent mutations in members of the gene regulatory and signaling machinery that control hematopoietic progenitor cell growth and differentiation. Here, we show that...
15.
Chin P, Assi S, Ptasinska A, Imperato M, Cockerill P, Bonifer C
Exp Hematol
. 2020 Nov;
92:62-74.
PMID: 33152396
Acute myeloid leukemia development occurs in a stepwise fashion whereby an original driver mutation is followed by additional mutations. The first type of mutations tends to be in genes encoding...
16.
Bevington S, Keane P, Soley J, Tauch S, Gajdasik D, Fiancette R, et al.
EMBO J
. 2020 Sep;
39(22):e105220.
PMID: 32930455
When dormant naïve T cells first become activated by antigen-presenting cells, they express the autocrine growth factor IL-2 which transforms them into rapidly dividing effector T cells. During this process,...
17.
Bevington S, Ng S, Britton G, Keane P, Wraith D, Cockerill P
Cell Rep
. 2020 Jun;
31(10):107748.
PMID: 32521273
Immunological homeostasis in T cells is maintained by a tightly regulated signaling and transcriptional network. Full engagement of effector T cells occurs only when signaling exceeds a critical threshold that...
18.
Ptasinska A, Pickin A, Assi S, Chin P, Ames L, Avellino R, et al.
Cell Rep
. 2019 Nov;
29(7):2120.
PMID: 31722222
No abstract available.
19.
Ptasinska A, Pickin A, Assi S, Chin P, Ames L, Avellino R, et al.
Cell Rep
. 2019 Sep;
28(12):3022-3031.e7.
PMID: 31533028
Acute myeloid leukemia (AML) is associated with mutations in transcriptional and epigenetic regulator genes impairing myeloid differentiation. The t(8;21)(q22;q22) translocation generates the RUNX1-ETO fusion protein, which interferes with the hematopoietic...
20.
Assi S, Bonifer C, Cockerill P
Cancer Inform
. 2019 Jul;
18:1176935119859863.
PMID: 31263370
Acute myeloid leukemia (AML) is a highly heterogeneous cancer associated with different patterns of gene expression determined by the nature of their DNA mutations. These mutations mostly act to deregulate...