Peter M Kekenes-Huskey
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Explore the profile of Peter M Kekenes-Huskey including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Cleary S, Teng A, Kongmeneck A, Fang X, Phillips T, Cho E, et al.
J Biol Chem
. 2024 Dec;
301(2):108118.
PMID: 39710323
The sarco(endo)plasmic reticulum Ca ATPase (SERCA) is a membrane transporter that creates and maintains intracellular Ca stores. In the heart, SERCA is regulated by an inhibitory interaction with the monomeric...
2.
Neupane K, Aryal S, Harvey B, Ramon G, Chun B, McCorkle J, et al.
Adv Healthc Mater
. 2024 Sep;
13(30):e2401906.
PMID: 39240019
Tumor-associated macrophages (TAMs) represent the majority of the immune cells present in the tumor microenvironment. These macrophages exhibit an anti-inflammatory (M2)-like physiological state and execute immune-suppressive and tumor-supporting properties. With...
3.
Donkervoort S, van de Locht M, Ronchi D, Reunert J, McLean C, Zaki M, et al.
Sci Transl Med
. 2024 Apr;
16(741):eadg2841.
PMID: 38569017
Troponin I (TnI) regulates thin filament activation and muscle contraction. Two isoforms, TnI-fast () and TnI-slow (), are predominantly expressed in fast- and slow-twitch myofibers, respectively. variants are a rare...
4.
Fang X, Bogdanov V, Davis J, Kekenes-Huskey P
J Chem Inf Model
. 2023 Nov;
63(23):7487-7498.
PMID: 38016288
Calmodulin (CaM) is a universal regulatory protein that modulates numerous cellular processes by using calcium (Ca) as the signal. In smooth muscle cells (SMC), one major target of CaM is...
5.
Rodriguez Garcia M, Schmeckpeper J, Landim-Vieira M, Coscarella I, Fang X, Ma W, et al.
Int J Mol Sci
. 2023 Oct;
24(19).
PMID: 37834023
The gene encodes α-actinin 2, located in the Z-disc of the sarcomeres in striated muscle. In this study, we sought to investigate the effects of an missense variant of unknown...
6.
Neupane K, Ramon G, Harvey B, Chun B, Aryal S, Masud A, et al.
Adv Healthc Mater
. 2023 Jun;
12(27):e2301163.
PMID: 37377147
Tumor-associated macrophages are the predominant immune cells present in the tumor microenvironment and mostly exhibit a pro-tumoral M2-like phenotype. However, macrophage biology is reversible allowing them to acquire an anti-tumoral...
7.
Human disease-associated calmodulin mutations alter calcineurin function through multiple mechanisms
Williams R, Afsar M, Tikunova S, Kou Y, Fang X, Somarathne R, et al.
Cell Calcium
. 2023 May;
113:102752.
PMID: 37245392
Calmodulin (CaM) is a ubiquitous, calcium-sensing protein that regulates a multitude of processes throughout the body. In response to changes in [Ca], CaM modifies, activates, and deactivates enzymes and ion...
8.
Immadisetty K, Fang X, Ramon G, Hartle C, McCoy T, Center R, et al.
J Mol Cell Cardiol
. 2023 May;
180:69-83.
PMID: 37187232
Congenital long QT syndrome (LQTS) is characterized by a prolonged QT-interval on an electrocardiogram (ECG). An abnormal prolongation in the QT-interval increases the risk for fatal arrhythmias. Genetic variants in...
9.
Chun B, Aryal S, Varughese P, Sun B, Bruno J, Richards C, et al.
Front Physiol
. 2023 Jan;
13:1037417.
PMID: 36699679
Adenosine triphosphate (ATP) and its metabolites drive microglia migration and cytokine production by activating P2X- and P2Y- class purinergic receptors. Purinergic receptor activation gives rise to diverse intracellular calcium (Ca2+...
10.
Sun B, Kekenes-Huskey P
Q Rev Biophys
. 2023 Jan;
56:e2.
PMID: 36628457
The cardiac sarcomere is a cellular structure in the heart that enables muscle cells to contract. Dozens of proteins belong to the cardiac sarcomere, which work in tandem to generate...