Peter L E M van Lent
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Explore the profile of Peter L E M van Lent including associated specialties, affiliations and a list of published articles.
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70
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1849
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Recent Articles
1.
Wang C, De Francesco R, Lamers L, Rinzema S, Frolich S, van Lent P, et al.
Rheumatology (Oxford)
. 2024 Mar;
64(2):860-869.
PMID: 38466933
Objectives: It is well-known that long-term osteoarthritis prognosis is not improved by corticosteroid treatments. Here we investigate what could underlie this phenomenon by measuring the short term corticosteroid response of...
2.
van Kooten N, Blom A, Teunissen van Manen I, Theeuwes W, Roth J, Gorris M, et al.
Rheumatology (Oxford)
. 2024 Jan;
64(1):332-343.
PMID: 38216750
Objectives: Macrophages are key orchestrators of the osteoarthritis (OA)-associated inflammatory response. Macrophage phenotype is dependent on environmental cues like the inflammatory factor S100A8/A9. Here, we investigated how S100A9 exposure during...
3.
Bartels Y, van Lent P, van der Kraan P, Blom A, Bonger K, van den Bosch M
Rheumatology (Oxford)
. 2023 Oct;
63(3):608-618.
PMID: 37788083
Local and systemic low-grade inflammation, mainly involving the innate immune system, plays an important role in the development of OA. A receptor playing a key role in initiation of this...
4.
Valdrighi N, Blom A, van Beuningen H, Vitters E, Helsen M, Walgreen B, et al.
PeerJ
. 2023 Jun;
11:e15482.
PMID: 37366428
Background: Osteoarthritis (OA) is a progressive joint disease and a major cause of chronic pain in adults. The prevalence of OA is higher in female patients, who tend to have...
5.
Teunissen van Manen I, van Kooten N, Di Ceglie I, Theeuwes W, Jimenez-Royo P, Cleveland M, et al.
Rheumatology (Oxford)
. 2023 Jun;
63(4):1180-1188.
PMID: 37341635
Objectives: OA is characterized by cartilage degeneration and persistent pain. The majority of OA patients present with synovitis, which is associated with increased cartilage damage. Activated synovial macrophages are key...
6.
Kruisbergen N, van Gemert Y, Blom A, van den Bosch M, van Lent P
Rheumatology (Oxford)
. 2022 Jul;
62(1):42-51.
PMID: 35863051
Synovial macrophages are key mediators of OA pathology, and skewing of macrophage phenotype in favour of an M1-like phenotype is thought to underlie the chronicity of synovial inflammation in OA....
7.
Thielen N, Neefjes M, Vitters E, van Beuningen H, Blom A, Koenders M, et al.
Cells
. 2022 Apr;
11(7).
PMID: 35406794
During osteoarthritis (OA), hypertrophy-like chondrocytes contribute to the disease process. TGF-β's signaling pathways can contribute to a hypertrophy(-like) phenotype in chondrocytes, especially at high doses of TGF-β. In this study,...
8.
Kruisbergen N, Di Ceglie I, van Gemert Y, Walgreen B, Helsen M, Sloetjes A, et al.
Antioxidants (Basel)
. 2021 Nov;
10(11).
PMID: 34829531
Osteoarthritis (OA) is a destructive disease of the joint with age and obesity being its most important risk factors. Around 50% of OA patients suffer from inflammation of the synovial...
9.
Di Ceglie I, van Lent P, Geven E, Koenders M, Blom A, Vogl T, et al.
Arthritis Res Ther
. 2021 Aug;
23(1):216.
PMID: 34412663
Background: Excessive osteoclast activity, which is strongly stimulated by pro-inflammatory mediators, results in bone and cartilage degeneration as central features of many arthritides. Levels of the alarmin S100A8/A9 and interleukin...
10.
Theeuwes W, van den Bosch M, Thurlings R, Blom A, van Lent P
Rheumatology (Oxford)
. 2021 Jan;
60(3):1042-1053.
PMID: 33410465
OA is a complex and highly prevalent degenerative disease affecting the whole joint, in which factors like genetic predisposition, gender, age, obesity and traumas contribute to joint destruction. ∼50-80% of...