Martijn H J van den Bosch
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Explore the profile of Martijn H J van den Bosch including associated specialties, affiliations and a list of published articles.
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278
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Recent Articles
1.
van der Kraan P, van Caam A, Blaney Davidson E, van den Bosch M, van de Loo F
Osteoarthr Cartil Open
. 2024 Mar;
6(2):100459.
PMID: 38486843
Introduction: Articular cartilage makes smooth movement possible and destruction of this tissue leads to loss of joint function. An important biomolecule that determines this function is the large aggregating proteoglycan...
2.
Wang C, De Francesco R, Lamers L, Rinzema S, Frolich S, van Lent P, et al.
Rheumatology (Oxford)
. 2024 Mar;
64(2):860-869.
PMID: 38466933
Objectives: It is well-known that long-term osteoarthritis prognosis is not improved by corticosteroid treatments. Here we investigate what could underlie this phenomenon by measuring the short term corticosteroid response of...
3.
van Kooten N, Blom A, Teunissen van Manen I, Theeuwes W, Roth J, Gorris M, et al.
Rheumatology (Oxford)
. 2024 Jan;
64(1):332-343.
PMID: 38216750
Objectives: Macrophages are key orchestrators of the osteoarthritis (OA)-associated inflammatory response. Macrophage phenotype is dependent on environmental cues like the inflammatory factor S100A8/A9. Here, we investigated how S100A9 exposure during...
4.
van den Bosch M, Blom A, van der Kraan P
Osteoarthritis Cartilage
. 2023 Dec;
32(4):355-364.
PMID: 38142733
Inflammation, both locally in the joint and systemic, is nowadays considered among the mechanisms involved in osteoarthritis (OA). However, this concept has not always been generally accepted. In fact, for...
5.
Bartels Y, van Lent P, van der Kraan P, Blom A, Bonger K, van den Bosch M
Rheumatology (Oxford)
. 2023 Oct;
63(3):608-618.
PMID: 37788083
Local and systemic low-grade inflammation, mainly involving the innate immune system, plays an important role in the development of OA. A receptor playing a key role in initiation of this...
6.
CD64 as novel molecular imaging marker for the characterization of synovitis in rheumatoid arthritis
Theeuwes W, Di Ceglie I, Dorst D, Blom A, Bos D, Vogl T, et al.
Arthritis Res Ther
. 2023 Aug;
25(1):158.
PMID: 37653557
Background: Rheumatoid arthritis (RA) is one of the most prevalent and debilitating joint diseases worldwide. RA is characterized by synovial inflammation (synovitis), which is linked to the development of joint...
7.
Thielen N, van Caam A, V Beuningen H, Vitters E, van den Bosch M, Koenders M, et al.
Osteoarthritis Cartilage
. 2023 Aug;
31(11):1481-1490.
PMID: 37652257
Objective: Transforming growth factor-β (TGF-β) signaling via SMAD2/3 is crucial to control cartilage homeostasis. However, TGF-β can also have detrimental effects by signaling via SMAD1/5/9 and thereby contribute to diseases...
8.
Timmermans R, Blom A, Nelissen R, Broekhuis D, van der Kraan P, Meulenbelt I, et al.
J Orthop Res
. 2023 Aug;
42(2):286-295.
PMID: 37525432
Dysregulation of Wingless and Int-1 (Wnt) signaling has been strongly associated with development and progression of osteoarthritis (OA). Here, we set out to investigate the independent effects of either mechanical...
9.
Teunissen van Manen I, van Kooten N, Di Ceglie I, Theeuwes W, Jimenez-Royo P, Cleveland M, et al.
Rheumatology (Oxford)
. 2023 Jun;
63(4):1180-1188.
PMID: 37341635
Objectives: OA is characterized by cartilage degeneration and persistent pain. The majority of OA patients present with synovitis, which is associated with increased cartilage damage. Activated synovial macrophages are key...
10.
Vago J, Valdrighi N, Blaney-Davidson E, Hornikx D, Neefjes M, Barba-Sarasua M, et al.
Pharmaceuticals (Basel)
. 2023 May;
16(5).
PMID: 37242486
Osteoarthritis (OA) is the most prevalent joint disease, and it is characterized by cartilage degeneration, synovitis, and bone sclerosis, resulting in swelling, stiffness, and joint pain. TAM receptors (Tyro3, Axl,...