Peter J M van Haastert
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Explore the profile of Peter J M van Haastert including associated specialties, affiliations and a list of published articles.
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90
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2738
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Recent Articles
1.
van Haastert P
Methods Mol Biol
. 2024 Aug;
2828:185-204.
PMID: 39147978
Amoeboid cells such as the protist Dictyostelium, human neutrophils, and the fungus B.d. chytrid move by extending pseudopods. The trajectories of cell movement depend on the size, rhythm, and direction...
2.
van Haastert P, Keizer-Gunnink I, Kortholt A
Methods Mol Biol
. 2024 Jul;
2814:177-194.
PMID: 38954206
Biochemical assays are described to analyze signal transduction by the second messenger cGMP in Dictyostelium. The methods include enzyme assays to measure the activity and regulation of cGMP synthesizing guanylyl...
3.
van Haastert P, Keizer-Gunnink I, Kortholt A
Methods Mol Biol
. 2024 Jul;
2814:133-147.
PMID: 38954203
Activation processes at the plasma membrane have been studied with life-cell imaging using GFP fused to a protein that binds to a component of the activation process. In this way,...
4.
van Haastert P, Keizer-Gunnink I, Pots H, Ortiz-Mateos C, Veltman D, van Egmond W, et al.
Mol Biol Cell
. 2021 Aug;
32(20):ar8.
PMID: 34347507
In , chemoattractants induce a fast cGMP response that mediates myosin filament formation in the rear of the cell. The major cGMP signaling pathway consists of a soluble guanylyl cyclase...
5.
Nederveen-Schippers L, Pathak P, Keizer-Gunnink I, Westphal A, van Haastert P, Borst J, et al.
Int J Mol Sci
. 2021 Jul;
22(14).
PMID: 34298920
Protein dimerization plays a crucial role in the regulation of numerous biological processes. However, detecting protein dimers in a cellular environment is still a challenge. Here we present a methodology...
6.
van Haastert P
PLoS One
. 2021 Feb;
16(2):e0246345.
PMID: 33571271
Amoeboid cells constantly change shape and extend protrusions. The direction of movement is not random, but is correlated with the direction of movement in the preceding minutes. The basis of...
7.
van Haastert P
PLoS One
. 2020 Dec;
15(12):e0243442.
PMID: 33296414
The trajectory of moving eukaryotic cells depends on the kinetics and direction of extending pseudopods. The direction of pseudopods has been well studied to unravel mechanisms for chemotaxis, wound healing...
8.
van Haastert P
Cells
. 2020 Aug;
9(8).
PMID: 32751539
The path of moving eukaryotic cells depends on the kinetics and direction of extending pseudopods. Amoeboid cells constantly change their shape with pseudopods extending in different directions. Detailed analysis has...
9.
van Haastert P, Keizer-Gunnink I, Kortholt A
J Cell Sci
. 2018 Mar;
131(7).
PMID: 29487182
Symmetry and symmetry breaking are essential in biology. Symmetry comes in different forms: rotational symmetry, mirror symmetry and alternating right-left symmetry (for example, gliding reflection symmetry). Especially the transitions between...
10.
Deyaert E, Wauters L, Guaitoli G, Konijnenberg A, Leemans M, Terheyden S, et al.
Nat Commun
. 2017 Oct;
8(1):1008.
PMID: 29044096
Mutations in LRRK2 are a common cause of genetic Parkinson's disease (PD). LRRK2 is a multi-domain Roco protein, harbouring kinase and GTPase activity. In analogy with a bacterial homologue, LRRK2...