Jeroen Roelofs
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Explore the profile of Jeroen Roelofs including associated specialties, affiliations and a list of published articles.
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36
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5687
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Recent Articles
1.
Kaur M, Chen X, Lee S, Weaver T, Freudenthal B, Walters K, et al.
bioRxiv
. 2024 Nov;
PMID: 39574619
Proteasomes are formed by chaperone-assisted assembly of core particles (CPs) and regulatory particles (RPs). The CP chaperone dimer Pba1/Pba2 binds early to proteasome subunits, and is thought to be replaced...
2.
Waite K, Vontz G, Lee S, Roelofs J
Proc Natl Acad Sci U S A
. 2024 Feb;
121(10):e2310756121.
PMID: 38408252
Stress conditions can cause the relocalization of proteasomes to condensates in yeast and mammalian cells. The interactions that facilitate the formation of proteasome condensates, however, are unclear. Here, we show...
3.
Waite K, Vontz G, Lee S, Roelofs J
bioRxiv
. 2023 Jul;
PMID: 37425862
Significance: Stress conditions can cause the relocalization of proteasomes to condensates in yeast as well as mammalian cells. Our work shows that the formation of proteasome condensates in yeast depends...
4.
Waite K, Roelofs J
J Cell Sci
. 2022 Aug;
135(17).
PMID: 35975718
In the yeast Saccharomyces cerevisiae, proteasomes are enriched in cell nuclei, in which they execute important cellular functions. Nutrient stress can change this localization, indicating that proteasomes respond to the...
5.
Waite K, Burris A, Vontz G, Lang A, Roelofs J
J Biol Chem
. 2021 Dec;
298(1):101494.
PMID: 34919962
Changing physiological conditions can increase the need for protein degradative capacity in eukaryotic cells. Both the ubiquitin-proteasome system and autophagy contribute to protein degradation. However, these processes can be differently...
6.
Schnell H, Walsh Jr R, Rawson S, Kaur M, Bhanu M, Tian G, et al.
Nat Struct Mol Biol
. 2021 Apr;
28(5):418-425.
PMID: 33846632
The proteasome mediates most selective protein degradation. Proteolysis occurs within the 20S core particle (CP), a barrel-shaped chamber with an αββα configuration. CP biogenesis proceeds through an ordered multistep pathway...
7.
Burris A, Waite K, Reuter Z, Ockerhausen S, Roelofs J
J Biol Chem
. 2021 Feb;
296:100468.
PMID: 33639167
The proteasome selectively degrades proteins. It consists of a core particle (CP), which contains proteolytic active sites that can associate with different regulators to form various complexes. How these different...
8.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
9.
Waite K, Burris A, Roelofs J
Sci Rep
. 2020 Oct;
10(1):18133.
PMID: 33093623
The efficient and timely degradation of proteins is crucial for many cellular processes and to maintain general proteostasis. The proteasome, a complex multisubunit protease, plays a critical role in protein...
10.
Suppahia A, Itagi P, Burris A, Kim F, Vontz A, Kante A, et al.
iScience
. 2020 May;
23(5):101090.
PMID: 32380419
Proteasomes are multi-subunit protease complexes found in all domains of life. The maturation of the core particle (CP), which harbors the active sites, involves dimerization of two half CPs (HPs)...