Peter J Gillespie
Overview
Explore the profile of Peter J Gillespie including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
903
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Recent Articles
1.
Kawasoe Y, Shimokawa S, Gillespie P, Blow J, Tsurimoto T, Takahashi T
J Biol Chem
. 2023 Dec;
300(1):105588.
PMID: 38141767
Proliferating cell nuclear antigen (PCNA) is a homo-trimeric clamp complex that serves as the molecular hub for various DNA transactions, including DNA synthesis and post-replicative mismatch repair. Its timely loading...
2.
Gillespie P, Blow J
Biology (Basel)
. 2022 Jun;
11(6).
PMID: 35741398
The maintenance of genomic stability during the mitotic cell-cycle not only demands that the DNA is duplicated and repaired with high fidelity, but that following DNA replication the chromatin composition...
3.
Volpi I, Gillespie P, Chadha G, Blow J
Open Biol
. 2021 Oct;
11(10):210121.
PMID: 34699733
Treslin/Ticrr is required for the initiation of DNA replication and binds to MTBP (Mdm2 Binding Protein). Here, we show that in egg extract, MTBP forms an elongated tetramer with Treslin...
4.
Shoaib M, Walter D, Gillespie P, Izard F, Fahrenkrog B, Lleres D, et al.
Nat Commun
. 2018 Sep;
9(1):3704.
PMID: 30209253
The decompaction and re-establishment of chromatin organization immediately after mitosis is essential for genome regulation. Mechanisms underlying chromatin structure control in daughter cells are not fully understood. Here we show...
5.
Gardner N, Gillespie P, Carrington J, Shanks E, McElroy S, Haagensen E, et al.
Cell Chem Biol
. 2017 Aug;
24(8):981-992.e4.
PMID: 28781123
In late mitosis and G, origins of DNA replication must be "licensed" for use in the upcoming S phase by being encircled by double hexamers of the minichromosome maintenance proteins...
6.
Alver R, Chadha G, Gillespie P, Blow J
Cell Rep
. 2017 Mar;
18(10):2508-2520.
PMID: 28273463
Dbf4-dependent kinases (DDKs) are required for the initiation of DNA replication, their essential targets being the MCM2-7 proteins. We show that, in Xenopus laevis egg extracts and human cells, hyper-phosphorylation...
7.
Chadha G, Gambus A, Gillespie P, Blow J
Cell Cycle
. 2016 Jun;
15(16):2183-2195.
PMID: 27327991
During S phase, following activation of the S phase CDKs and the DBF4-dependent kinases (DDK), double hexamers of Mcm2-7 at licensed replication origins are activated to form the core replicative...
8.
Gillespie P, Neusiedler J, Creavin K, Chadha G, Blow J
Methods Mol Biol
. 2015 Aug;
1342:101-47.
PMID: 26254920
Many important discoveries in cell cycle research have been made using cell-free extracts prepared from the eggs of the South African clawed frog Xenopus laevis. These extracts efficiently support the...
9.
Poh W, Chadha G, Gillespie P, Kaldis P, Blow J
Open Biol
. 2014 Jan;
4:130138.
PMID: 24403013
The initiation of DNA replication requires two protein kinases: cyclin-dependent kinase (Cdk) and Cdc7. Although S phase Cdk activity has been intensively studied, relatively little is known about how Cdc7...
10.
Caillat C, Pefani D, Gillespie P, Taraviras S, Blow J, Lygerou Z, et al.
J Biol Chem
. 2013 Sep;
288(44):31624-34.
PMID: 24064211
Geminin is an important regulator of proliferation and differentiation in metazoans, which predominantly inhibits the DNA replication licensing factor Cdt1, preventing genome over-replication. We show that Geminin preferentially forms stable...