Jens S Andersen
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Explore the profile of Jens S Andersen including associated specialties, affiliations and a list of published articles.
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113
Citations
7875
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Recent Articles
1.
Imamura K, Garland W, Schmid M, Jakobsen L, Sato K, Rouviere J, et al.
Mol Cell
. 2024 Nov;
84(21):4158-4174.e6.
PMID: 39515294
In mammalian cells, primary miRNAs are cleaved at their hairpin structures by the Microprocessor complex, whose core is composed of DROSHA and DGCR8. Here, we show that 5' flanking regions,...
2.
Schou K, Mandacaru S, Tahir M, Tom N, Nilsson A, Andersen J, et al.
Nat Commun
. 2024 Sep;
15(1):7748.
PMID: 39237506
Evolutionary annotation of genome maintenance (GM) proteins has conventionally been established by remote relationships within protein sequence databases. However, often no significant relationship can be established. Highly sensitive approaches to...
3.
Andersen J, Vijayakumaran A, Godbehere C, Lorentzen E, Mennella V, Schou K
Nat Commun
. 2024 Mar;
15(1):2687.
PMID: 38538594
Centrosomes and cilia are microtubule-based superstructures vital for cell division, signaling, and motility. The once thought hollow lumen of their microtubule core structures was recently found to hold a rich...
4.
Polak P, Garland W, Rathore O, Schmid M, Salerno-Kochan A, Jakobsen L, et al.
Cell Rep
. 2023 Oct;
42(11):113325.
PMID: 37889751
The RNA exosome is a versatile ribonuclease. In the nucleoplasm of mammalian cells, it is assisted by its adaptors the nuclear exosome targeting (NEXT) complex and the poly(A) exosome targeting...
5.
Kuhns S, Juhl A, Anvarian Z, Wustner D, Pedersen L, Andersen J
Methods Mol Biol
. 2023 Oct;
2725:147-166.
PMID: 37856023
CRISPR-mediated endogenous tagging of genes provides unique possibilities to explore the function and dynamic subcellular localization of proteins in living cells. Here, we describe experimental strategies for endogenous PCR-tagging of...
6.
Boegholm N, Petriman N, Loureiro-Lopez M, Wang J, Vela M, Liu B, et al.
EMBO J
. 2023 Aug;
42(18):e111807.
PMID: 37606072
Cilia are important cellular organelles for signaling and motility and are constructed via intraflagellar transport (IFT). RabL2 is a small GTPase that localizes to the basal body of cilia via...
7.
Rouviere J, Salerno-Kochan A, Lykke-Andersen S, Garland W, Dou Y, Rathore O, et al.
Mol Cell
. 2023 Jun;
83(13):2240-2257.e6.
PMID: 37329882
The RNA-binding ARS2 protein is centrally involved in both early RNA polymerase II (RNAPII) transcription termination and transcript decay. Despite its essential nature, the mechanisms by which ARS2 enacts these...
8.
Petriman N, Loureiro-Lopez M, Taschner M, Zacharia N, Georgieva M, Boegholm N, et al.
EMBO J
. 2022 Nov;
41(24):e112440.
PMID: 36354106
Cilia are ubiquitous eukaryotic organelles impotant for cellular motility, signaling, and sensory reception. Cilium formation requires intraflagellar transport of structural and signaling components and involves 22 different proteins organized into...
9.
Juhl A, Anvarian Z, Kuhns S, Berges J, Andersen J, Wustner D, et al.
J Cell Sci
. 2022 Apr;
136(5).
PMID: 35403186
Primary cilia are microtubule-based sensory organelles whose assembly and function rely on the conserved bidirectional intraflagellar transport (IFT) system, which is powered by anterograde kinesin-2 and retrograde cytoplasmic dynein-2 motors....
10.
Gockert M, Schmid M, Jakobsen L, Jens M, Andersen J, Jensen T
Nucleic Acids Res
. 2022 Jan;
50(3):1583-1600.
PMID: 35048984
Turnover of nucleoplasmic transcripts by the mammalian multi-subunit RNA exosome is mediated by two adaptors: the Nuclear EXosome Targeting (NEXT) complex and the Poly(A) tail eXosome Targeting (PAXT) connection. Functional...