Peter J Facchini
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Explore the profile of Peter J Facchini including associated specialties, affiliations and a list of published articles.
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107
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2768
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Recent Articles
1.
Carr S, Rehman F, Hagel J, Chen X, Ng K, Facchini P
Commun Biol
. 2024 Oct;
7(1):1410.
PMID: 39472466
The evolution of morphinan alkaloid biosynthesis in plants of the genus Papaver includes permutation of several processes including gene duplication, fusion, neofunctionalization, and deletion resulting in the present chemotaxonomy. A...
2.
Li G, Facchini P
Curr Opin Plant Biol
. 2024 Sep;
82:102626.
PMID: 39288539
The recent relaxation of psychedelic drug regulations has prompted extensive clinical investigation into their potential use to treat diverse mental health conditions including anxiety, depression, post-traumatic stress, and substance-abuse disorders....
3.
Carr S, Facchini P, Ng K
Acta Crystallogr D Struct Biol
. 2024 Aug;
80(Pt 9):675-685.
PMID: 39207895
Several proteins from plant pathogenesis-related family 10 (PR10) are highly abundant in the latex of opium poppy and have recently been shown to play diverse and important roles in the...
4.
Raithatha S, Hagel J, Matinkhoo K, Yu L, Press D, Cook S, et al.
J Med Chem
. 2023 Nov;
67(2):1024-1043.
PMID: 37983270
The psychedelic prodrug psilocybin has shown therapeutic benefits for the treatment of numerous psychiatric conditions. Despite positive clinical end points targeting depression and anxiety, concerns regarding the duration of the...
5.
Chen X, Li J, Yu L, Maule F, Chang L, Gallant J, et al.
J Biol Chem
. 2023 Sep;
299(10):105231.
PMID: 37690691
Psychedelic indolethylamines have emerged as potential medicines to treat several psychiatric pathologies. Natural sources of these compounds include 'magic mushrooms' (Psilocybe spp.), plants used to prepare ayahuasca, and toads. The...
6.
Watkins J, Li Q, Yeaman S, Facchini P
Plant J
. 2023 Sep;
116(3):635-649.
PMID: 37675639
Peyote (Lophophora williamsii) is an entheogenic and medicinal cactus native to the Chihuahuan desert. The psychoactive and hallucinogenic properties of peyote are principally attributed to the phenethylamine derivative mescaline. Despite...
7.
Menendez-Perdomo I, Facchini P
Sci Rep
. 2023 Feb;
13(1):2955.
PMID: 36805479
Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant specialized metabolites found mainly in members of the order Ranunculales, including opium poppy (Papaver somniferum), for which BIA biosynthetic pathways...
8.
Ozber N, Yu L, Hagel J, Facchini P
ACS Chem Biol
. 2023 Feb;
18(2):419-430.
PMID: 36735832
Systematic screening of morphine pathway intermediates in engineered yeast revealed key biosynthetic enzymes displaying potent feedback inhibition: 3'-hydroxy--methylcoclaurine 4'-methyltransferase (4'OMT), which yields ()-reticuline, and the coupled salutaridinol-7--acetyltransferase (SalAT) and thebaine...
9.
Ozber N, Carr S, Morris J, Liang S, Watkins J, Caldo K, et al.
Nat Commun
. 2022 Nov;
13(1):6768.
PMID: 36351903
Opium poppy accumulates copious amounts of several benzylisoquinoline alkaloids including morphine, noscapine, and papaverine, in the specialized cytoplasm of laticifers, which compose an internal secretory system associated with phloem throughout...
10.
Ozber N, Facchini P
J Plant Physiol
. 2022 Mar;
271:153641.
PMID: 35240512
Opium poppy is the only commercial source of the narcotic analgesics morphine and codeine, and semi-synthetic derivatives of the natural opiate precursor thebaine, including oxycodone and the opioid antagonist naloxone....