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David J Elliot

Explore the profile of David J Elliot including associated specialties, affiliations and a list of published articles. Areas
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Articles 28
Citations 536
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Recent Articles
1.
Tran L, Kichenadasse G, Morel K, Lavranos T, Klebe S, Lower K, et al.
In Vivo . 2018 Dec; 33(1):99-108. PMID: 30587609
Background/aim: The hypoglycemic drug metformin (MET) and the anti-epileptic drug valproic acid (VPA) have individually shown anti-tumor effects in prostate cancer in vitro. The present study intended to investigate the...
2.
White R, Pulford E, Elliot D, Thurgood L, Klebe S
J Proteomics . 2018 Oct; 192:374-382. PMID: 30300743
Malignant pleural mesothelioma (MPM) is a devastating malignancy with a prognosis of <12 months. Even with bans on the use of asbestos in most Western countries, the incidence is still...
3.
Bendikov M, Miners J, Simpson B, Elliot D, Semple S, Claudie D, et al.
Xenobiotica . 2016 Jul; 47(6):461-469. PMID: 27412850
1. The metabolism of the anti-inflammatory diterpenoid polyandric acid A (PAA), a constituent of the Australian Aboriginal medicinal plant Dodonaea polyandra, and its de-esterified alcohol metabolite, hydrolysed polyandric acid A...
4.
Izuogu O, Alhasan A, Alafghani H, Santibanez-Koref M, Elliott D, Elliot D, et al.
BMC Bioinformatics . 2016 Jan; 17:31. PMID: 26758031
Background: Transcripts, which have been subject to Post-transcriptional exon shuffling (PTES), have an exon order inconsistent with the underlying genomic sequence. These have been identified in a wide variety of...
5.
Chau N, Elliot D, Lewis B, Burns K, Johnston M, Mackenzie P, et al.
J Pharmacol Exp Ther . 2014 Jan; 349(1):126-37. PMID: 24459244
Morphine 3-β-D-glucuronide (M3G) and morphine 6-β-D-glucuronide (M6G) are the major metabolites of morphine in humans. More recently, morphine-3-β-d-glucoside (M-3-glucoside) was identified in the urine of patients treated with morphine. Kinetic...
6.
Polasek T, Elliot D, Miners J
Curr Protoc Toxicol . 2012 Oct; Chapter 4:Unit4.19. PMID: 23045133
Cytochrome P4501A2 (CYP1A2) is responsible for the metabolism of a diverse range of clinically used drugs and dietary and environmental chemicals (including many procarcinogens). CYP1A2 expression is influenced by numerous...
7.
Wattanachai N, Tassaneeyakul W, Rowland A, Elliot D, Bowalgaha K, Knights K, et al.
Drug Metab Dispos . 2012 Feb; 40(5):982-9. PMID: 22331994
Long-chain unsaturated fatty acids inhibit several cytochrome P450 and UDP-glucuronosyltransferase (UGT) enzymes involved in drug metabolism, including CYP2C8, CYP2C9, UGT1A9, UGT2B4, and UGT2B7. Bovine serum albumin (BSA) enhances these cytochrome...
8.
McLure J, Birkett D, Elliot D, Williams J, Rowland A, Miners J
Drug Metab Dispos . 2011 May; 39(9):1711-7. PMID: 21610127
The fluorescence of 1-anilinonaphthalene-8-sulfonate (ANS) in the presence of human liver microsomes (HLMs) is altered by drugs that bind nonspecifically to the lipid bilayer. The present study characterized the relationship...
9.
Miners J, Bowalgaha K, Elliot D, Baranczewski P, Knights K
Drug Metab Dispos . 2011 Jan; 39(4):644-52. PMID: 21245288
Enzyme selective inhibitors represent the most valuable experimental tool for reaction phenotyping. However, only a limited number of UDP-glucuronosyltransferase (UGT) enzyme-selective inhibitors have been identified to date. This study characterized...
10.
Mackenzie P, Rogers A, Elliot D, Chau N, Hulin J, Miners J, et al.
Mol Pharmacol . 2010 Nov; 79(3):472-8. PMID: 21088224
The human UDP glycosyltransferase (UGT) 3A family is one of three families involved in the metabolism of small lipophilic compounds. Members of these families catalyze the addition of sugar residues...