Peter Humphries
Overview
Explore the profile of Peter Humphries including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
77
Citations
2425
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
OCallaghan J, Delaney C, OConnor M, van Batenburg-Sherwood J, Schicht M, Lutjen-Drecoll E, et al.
Sci Adv
. 2023 Apr;
9(16):eadf6537.
PMID: 37075118
Approximately 80 million people globally are affected by glaucoma, with a projected increase to over 110 million by 2040. Substantial issues surrounding patient compliance remain with topical eye drops, and...
2.
Chadderton N, Palfi A, Maloney D, Carrigan M, Finnegan L, Hanlon K, et al.
Pharmaceutics
. 2023 Feb;
15(2).
PMID: 36839646
AAV gene therapy for ocular disease has become a reality with the market authorisation of Luxturna for RPE65-linked inherited retinal degenerations and many AAV gene therapies currently undergoing phase III...
3.
McDowell C, Kizhatil K, Elliott M, Overby D, van Batenburg-Sherwood J, Millar J, et al.
Invest Ophthalmol Vis Sci
. 2022 Feb;
63(2):12.
PMID: 35129590
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular...
4.
Maloney D, Chadderton N, Millington-Ward S, Palfi A, Shortall C, OByrne J, et al.
Front Neurosci
. 2020 Dec;
14:571479.
PMID: 33324145
Optic Atrophy 1 (OPA1) is a mitochondrially targeted GTPase that plays a pivotal role in mitochondrial health, with mutations causing severe mitochondrial dysfunction and typically associated with Dominant Optic Atrophy...
5.
Millington-Ward S, Chadderton N, Berkeley M, Finnegan L, Hanlon K, Carrigan M, et al.
Sci Rep
. 2020 Oct;
10(1):16515.
PMID: 33020509
Retinal ganglion cells (RGCs) are known to be involved in several ocular disorders, including glaucoma and Leber hereditary optic neuropathy (LHON), and hence represent target cells for gene therapies directed...
6.
Whelan L, Dockery A, Wynne N, Zhu J, Stephenson K, Silvestri G, et al.
Genes (Basel)
. 2020 Jan;
11(1).
PMID: 31963381
The Irish national registry for inherited retinal degenerations (Target 5000) is a clinical and scientific program to identify individuals in Ireland with inherited retinal disorders and to attempt to ascertain...
7.
Reina-Torres E, Bertrand J, OCallaghan J, Sherwood J, Humphries P, Overby D
Exp Eye Res
. 2019 Jul;
186:107745.
PMID: 31351057
Mice are routinely used to study aqueous humour dynamics. However, physical factors such as temperature and hydration affect outflow facility in enucleated eyes. This retrospective study examined whether differences in...
8.
OCallaghan J, Campbell M, Humphries P
Methods Mol Biol
. 2019 Feb;
1950:263-270.
PMID: 30783979
AAV9 drives gene expression in a highly selective manner within the corneal endothelium of mice following intracameral inoculation into the anterior chamber of the eye. In principle, this allows genes...
9.
Crosbie D, Keaney J, Tam L, Stamer W, Campbell M, Humphries P
Magn Reson Imaging
. 2019 Jan;
59:10-16.
PMID: 30660703
Purpose: Here, we are testing the hypothesis that dynamic contrast enhanced MRI (DCE-MRI) is a useful approach for non-invasively evaluating age-related changes in aqueous humor outflow and its contribution to...
10.
Dockery A, Stephenson K, Keegan D, Wynne N, Silvestri G, Humphries P, et al.
Genes (Basel)
. 2017 Nov;
8(11).
PMID: 29099798
There are an estimated 5000 people in Ireland who currently have an inherited retinal degeneration (IRD). It is the goal of this study, through genetic diagnosis, to better enable these...