James M Ervasti
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Explore the profile of James M Ervasti including associated specialties, affiliations and a list of published articles.
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87
Citations
2927
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Recent Articles
1.
Ervasti J, Kashina A, Perrin B
Nat Commun
. 2025 Mar;
16(1):2240.
PMID: 40055341
No abstract available.
2.
Streeter O, Shi K, Vavra J, Aihara H, Ervasti J, Evans 3rd R, et al.
Acta Crystallogr D Struct Biol
. 2025 Feb;
81(Pt 3):122-129.
PMID: 40007458
The structure of the N-terminal actin-binding domain of human dystrophin was determined at 1.94 Å resolution. Each chain in the asymmetric unit exists in a `closed' conformation, with the first...
3.
Johnson E, Ervasti J
FEBS J
. 2025 Feb;
PMID: 39985215
Duchenne muscular dystrophy is a severe neuromuscular wasting disease that is caused by a primary defect in dystrophin protein and involves organism-wide comorbidities such as cardiomyopathy, metabolic and mitochondrial dysfunction,...
4.
Southern W, Johnson E, Fasbender E, Fallon K, Cavazos C, Lowe D, et al.
J Clin Invest
. 2025 Jan;
135(5).
PMID: 39808494
Eccentric contraction-induced (ECC-induced) force loss is a hallmark of murine dystrophin-deficient (mdx) skeletal muscle that is used to assess efficacy of potential therapies for Duchenne muscular dystrophy. While virtually all...
5.
Hua C, Slick R, Vavra J, Muretta J, Ervasti J, Salapaka M
bioRxiv
. 2024 Jun;
PMID: 38826288
Duchenne muscular dystrophy (DMD) is a lethal muscle disease caused by the absence of the protein dystrophin. Dystrophin is hypothesized to work as a molecular shock absorber that limits myofiber...
6.
Duvick L, Southern W, Benzow K, Burch Z, Handler H, Mitchell J, et al.
JCI Insight
. 2024 Mar;
9(9.
PMID: 38512434
Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by an expanded polyglutamine tract in the widely expressed ataxin-1 (ATXN1) protein. To elucidate anatomical regions and cell types...
7.
Sundby L, Southern W, Sun J, Patrinostro X, Zhang W, Yong J, et al.
Eur J Cell Biol
. 2024 Feb;
103(2):151397.
PMID: 38387258
The cytoplasmic actin proteins, β- and γ-actin, are 99% identical but thought to perform non-redundant functions. The nucleotide coding regions of cytoplasmic actin genes, Actb and Actg1, are 89% identical....
8.
Johnson E, Southern W, Doud B, Steiger B, Razzoli M, Bartolomucci A, et al.
Hum Mol Genet
. 2024 Jan;
33(7):594-611.
PMID: 38181046
Duchenne muscular dystrophy (DMD) is a lethal degenerative muscle wasting disease caused by the loss of the structural protein dystrophin with secondary pathological manifestations including metabolic dysfunction, mood and behavioral...
9.
Duvick L, Southern W, Benzow K, Burch Z, Handler H, Mitchell J, et al.
bioRxiv
. 2023 Feb;
PMID: 36798410
Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by an expanded polyglutamine tract in the widely expressed ATXN1 protein. To elucidate anatomical regions and cell types that...
10.
Ramirez M, Rajaganapathy S, Hagerty A, Hua C, Baxter G, Vavra J, et al.
J Biol Chem
. 2023 Jan;
299(2):102847.
PMID: 36587764
Duchenne muscular dystrophy is a lethal muscle wasting disease caused by the absence of the protein dystrophin. Utrophin is a dystrophin homologue currently under investigation as a protein replacement therapy...