Peter A Wilce
Overview
Explore the profile of Peter A Wilce including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
358
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0
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Recent Articles
1.
Toselli F, de Waziers I, Dutheil M, Vincent M, Wilce P, Dodd P, et al.
Xenobiotica
. 2015 Jun;
45(12):1129-37.
PMID: 26095139
1. Ethanol consumption and smoking alter the expression of certain drug-metabolizing enzymes and transporters, potentially influencing the tissue-specific effects of xenobiotics. 2. Amygdala (AMG) and prefrontal cortex (PFC) are brain...
2.
Toselli F, Booth Depaz I, Worrall S, Etheridge N, Dodd P, Wilce P, et al.
Alcohol Clin Exp Res
. 2015 Apr;
39(5):790-7.
PMID: 25872594
Background: The tissue-specific expression of cytochrome P450 enzymes (CYP, P450) in the human brain may influence the therapeutic response to, and side effects of, neuroactive drugs including alcohol. However, the...
3.
Booth Depaz I, Toselli F, Wilce P, Gillam E
Drug Metab Dispos
. 2014 Dec;
43(3):353-7.
PMID: 25504503
Cytochrome P450 enzymes from the CYP2C subfamily play a prominent role in the metabolic clearance of many drugs. CYP2C enzymes have also been implicated in the metabolism of arachidonic acid...
4.
Booth Depaz I, Toselli F, Wilce P, Gillam E
Drug Metab Dispos
. 2013 Mar;
41(6):1187-94.
PMID: 23491640
Cytochrome P450 enzymes are responsible for the metabolism of most commonly used drugs. Among these enzymes, CYP3A forms mediate the clearance of around 40-50% of drugs and may also play...
5.
Kryger R, Fan L, Wilce P, Jaquet V
Alcohol
. 2012 May;
46(7):629-34.
PMID: 22560368
Chronic alcohol intake induces neurochemical adaptative changes in the brain characterised by altered gene expression. A role for non-coding RNAs in alcoholism is beginning to emerge. PCR-differential display using total...
6.
Matsumoto A, Mason S, Flatscher-Bader T, Ward L, Marsh S, Wilce P, et al.
Int J Cardiol
. 2011 Feb;
158(1):59-65.
PMID: 21295869
Background: The molecular mechanisms of exercise training induced cardiovascular protection are poorly understood. There is growing evidence that reactive oxygen species may be involved in a number of these adaptations...
7.
Flatscher-Bader T, Harrison E, Matsumoto I, Wilce P
Alcohol Clin Exp Res
. 2010 May;
34(7):1291-302.
PMID: 20477762
Background: The incidence of alcohol and tobacco co-abuse is as high as 80%. The molecular mechanism underlying this comorbidity is virtually unknown, but interactions between these drugs have important implications...
8.
Flatscher-Bader T, Wilce P
Nutr Res Rev
. 2009 Nov;
22(2):148-62.
PMID: 19900347
Alcohol intake at levels posing an acute heath risk is common amongst teenagers. Alcohol abuse is the second most common mental disorder worldwide. The incidence of smoking is decreasing in...
9.
Miki T, Yokoyama T, Sumitani K, Kusaka T, Warita K, Matsumoto Y, et al.
Congenit Anom (Kyoto)
. 2008 Sep;
48(3):110-7.
PMID: 18778455
Maternal alcohol ingestion during pregnancy adversely affects the developing fetus, often leading to fetal alcohol syndrome (FAS). One of the most severe consequences of FAS is brain damage that is...
10.
Flatscher-Bader T, Wilce P
Alcohol Clin Exp Res
. 2008 Jul;
32(10):1849-58.
PMID: 18657127
Background: Alcoholism is associated with shrinkage of brain tissue and reduction in the number of neurons and dendritic arbors particularly in the prefrontal cortex. These changes correlate with the cognitive...