Peter-Christian Klohn
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Explore the profile of Peter-Christian Klohn including associated specialties, affiliations and a list of published articles.
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15
Citations
630
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Recent Articles
1.
Ribes J, Patel M, Halim H, Berretta A, Tooze S, Klohn P
Nat Commun
. 2023 Dec;
14(1):8354.
PMID: 38102121
The self-templating nature of prions plays a central role in prion pathogenesis and is associated with infectivity and transmissibility. Since propagation of proteopathic seeds has now been acknowledged a principal...
2.
Bhamra S, Arora P, Manka S, Schmidt C, Brown C, Rayner M, et al.
J Mol Biol
. 2022 Dec;
435(4):167925.
PMID: 36535427
To dissect the N-terminal residues within the cellular prion protein (PrP) that are critical for efficient prion propagation, we generated a library of point, double, or triple alanine replacements within...
3.
Philiastides A, Ribes J, Yip D, Schmidt C, Benilova I, Klohn P
Viruses
. 2019 Sep;
11(10).
PMID: 31546723
Prion diseases are fatal neurodegenerative diseases that affect humans and animals. Prion strains, conformational variants of misfolded prion proteins, are associated with distinct clinical and pathological phenotypes. Host-strain interactions result...
4.
Marbiah M, Harvey A, West B, Louzolo A, Banerjee P, Alden J, et al.
EMBO J
. 2014 May;
33(14):1527-47.
PMID: 24843046
Prions consist of aggregates of abnormal conformers of the cellular prion protein (PrP(C)). They propagate by recruiting host-encoded PrP(C) although the critical interacting proteins and the reasons for the differences...
5.
Klohn P, Castro-Seoane R, Collinge J
J Infect
. 2013 Aug;
67(5):359-68.
PMID: 23911964
Prion diseases are incurable transmissible neurological disorders. In many natural and experimental prion diseases, infectious prions can be detected in the lymphoreticular system (LRS) long before they reach the brain...
6.
Klohn P, Wuellner U, Zizlsperger N, Zhou Y, Tavares D, Berger S, et al.
MAbs
. 2013 Apr;
5(2):178-201.
PMID: 23575266
The 23rd Annual Antibody Engineering, 10th Annual Antibody Therapeutics international conferences, and the 2012 Annual Meeting of The Antibody Society, organized by IBC Life Sciences with contributions from The Antibody...
7.
Castro-Seoane R, Hummerich H, Sweeting T, Tattum M, Linehan J, Fernandez de Marco M, et al.
PLoS Pathog
. 2012 Feb;
8(2):e1002538.
PMID: 22359509
In most transmissible spongiform encephalopathies prions accumulate in the lymphoreticular system (LRS) long before they are detectable in the central nervous system. While a considerable body of evidence showed that...
8.
Klohn P, Farmer M, Linehan J, OMalley C, Fernandez de Marco M, Taylor W, et al.
Science
. 2012 Jan;
335(6064):52.
PMID: 22223800
Intraperitoneal administration of ICSM18 and 35, monoclonal antibodies against prion protein (PrP), has been shown to significantly delay the onset of prion disease in mice, and humanized versions are candidate...
9.
Mahal S, Demczyk C, Smith Jr E, Klohn P, Weissmann C
Methods Mol Biol
. 2008 Jun;
459:49-68.
PMID: 18576147
Prions are usually quantified by bioassays based on intracerebral inoculation of animals, which are slow, imprecise, and costly. We have developed a cell-based prion assay that is based on the...
10.
Julius C, Hutter G, Wagner U, Seeger H, Kana V, Kranich J, et al.
J Mol Biol
. 2007 Dec;
375(5):1222-33.
PMID: 18082765
Prion infections induce severe disruption of the central nervous system with neuronal vacuolation and extensive glial reactions, and invariably lead to death of affected individuals. The molecular underpinnings of these...