Peter-Christian Klohn
Overview
Explore the profile of Peter-Christian Klohn including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
630
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Recent Articles
11.
Kristiansen M, Messenger M, Klohn P, Brandner S, Wadsworth J, Collinge J, et al.
J Biol Chem
. 2005 Sep;
280(46):38851-61.
PMID: 16157591
The molecular basis for neuronal death in prion disease is not established, but putative pathogenic roles for both disease-related prion protein (PrP(Sc)) and accumulated cytosolic PrP(C) have been proposed. Here...
12.
Heikenwalder M, Zeller N, Seeger H, Prinz M, Klohn P, Schwarz P, et al.
Science
. 2005 Jan;
307(5712):1107-10.
PMID: 15661974
Prions typically accumulate in nervous and lymphoid tissues. Because proinflammatory cytokines and immune cells are required for lymphoid prion replication, we tested whether inflammatory conditions affect prion pathogenesis. We administered...
13.
Mallucci G, Dickinson A, Linehan J, Klohn P, Brandner S, Collinge J
Science
. 2003 Nov;
302(5646):871-4.
PMID: 14593181
The mechanisms involved in prion neurotoxicity are unclear, and therapies preventing accumulation of PrPSc, the disease-associated form of prion protein (PrP), do not significantly prolong survival in mice with central...
14.
Klohn P, Soriano M, Irwin W, Penzo D, Scorrano L, Bitsch A, et al.
Proc Natl Acad Sci U S A
. 2003 Aug;
100(17):10014-9.
PMID: 12907702
A hallmark of tumorigenesis is resistance to apoptosis. To explore whether resistance to cell death precedes tumor formation, we have studied the short-term effects of the hepatocarcinogen 2-acetylaminofluorene (AAF) on...
15.
Weissmann C, Enari M, Klohn P, Rossi D, Flechsig E
Acta Neurobiol Exp (Wars)
. 2002 Nov;
62(3):153-66.
PMID: 12416393
The "protein only" hypothesis holds that the infectious agent causing transmissible spongiform encephalopathies is a conformational isomer of PrP, a host protein predominantly expressed in brain and is strongly supported...