Percival Yang-Ting Chen
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Explore the profile of Percival Yang-Ting Chen including associated specialties, affiliations and a list of published articles.
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17
Citations
258
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Recent Articles
1.
Coco L, Toci E, Chen P, Drennan C, Freel Meyers C
ACS Infect Dis
. 2024 Mar;
10(4):1312-1326.
PMID: 38513073
New antimicrobial strategies are needed to address pathogen resistance to currently used antibiotics. Bacterial central metabolism is a promising target space for the development of agents that selectively target bacterial...
2.
Cordoza J, Chen P, Blaustein L, Lima S, Fiore M, Chekan J, et al.
ACS Catal
. 2023 Jul;
13(14):9817-9828.
PMID: 37497377
Cyclic arginine noncanonical amino acids (ncAAs) are found in several actinobacterial peptide natural products with therapeutically useful antibacterial properties. The preparation of ncAAs like enduracididine and capreomycidine currently takes multiple...
3.
Cordoza J, Chen P, Blaustein L, Lima S, Fiore M, Chekan J, et al.
bioRxiv
. 2023 Mar;
PMID: 36993528
Cyclic arginine noncanonical amino acids (ncAAs) are found in several actinobacterial peptide natural products with therapeutically useful antibacterial properties. The preparation of ncAAs like enduracididine and capreomycidine currently takes multiple...
4.
Chen P, Adak S, Chekan J, Liscombe D, Miyanaga A, Bernhardt P, et al.
Biochemistry
. 2022 Aug;
61(17):1844-1852.
PMID: 35985031
Vanadium-dependent haloperoxidases (VHPOs) from bacteria differ from their counterparts in fungi, macroalgae, and other bacteria by catalyzing organohalogenating reactions with strict regiochemical and stereochemical control. While this group of enzymes...
5.
Burkhardt I, de Rond T, Chen P, Moore B
Nat Chem Biol
. 2022 May;
18(6):664-669.
PMID: 35606558
Octocorals are major contributors of terpenoid chemical diversity in the ocean. Natural products from other sessile marine animals are primarily biosynthesized by symbiotic microbes rather than by the host. Here,...
6.
Bauman K, Shende V, Chen P, B B Trivella D, Gulder T, Vellalath S, et al.
Nat Chem Biol
. 2022 Mar;
18(5):538-546.
PMID: 35314816
The marine microbial natural product salinosporamide A (marizomib) is a potent proteasome inhibitor currently in clinical trials for the treatment of brain cancer. Salinosporamide A is characterized by a complex...
7.
Ohmer C, Dasgupta M, Patwardhan A, Bogacz I, Kaminsky C, Doyle M, et al.
J Inorg Biochem
. 2022 Feb;
230:111768.
PMID: 35202981
Methyl-Coenzyme M Reductase (MCR) catalyzes the biosynthesis of methane in methanogenic archaea, using a catalytic Ni-centered Cofactor F430 in its active site. It also catalyzes the reverse reaction, that is,...
8.
Knox H, Chen P, Blaszczyk A, Mukherjee A, Grove T, Schwalm E, et al.
Nat Chem Biol
. 2021 Jan;
17(4):485-491.
PMID: 33462497
Tryptophan 2C methyltransferase (TsrM) methylates C2 of the indole ring of L-tryptophan during biosynthesis of the quinaldic acid moiety of thiostrepton. TsrM is annotated as a cobalamin-dependent radical S-adenosylmethionine (SAM)...
9.
Chen P, DeColli A, Freel Meyers C, Drennan C
J Biol Chem
. 2019 Jun;
294(33):12405-12414.
PMID: 31239351
1-Deoxy-d-xylulose 5-phosphate synthase (DXPS) uses thiamine diphosphate (ThDP) to convert pyruvate and d-glyceraldehyde 3-phosphate (d-GAP) into 1-deoxy-d-xylulose 5-phosphate (DXP), an essential bacterial metabolite. DXP is not utilized by humans; hence,...
10.
Chen P, Li B, Drennan C, Elliott S
Joule
. 2019 May;
3(2):595-611.
PMID: 31080943
2-oxoglutarate:ferredoxin oxidoreductase (OGOR) is a thiamine pyrophosphate (TPP) and [4Fe-4S] cluster-dependent enzyme from the reductive tricarboxylic acid (rTCA) cycle that fixes CO to succinyl-CoA, forming 2-oxoglutarate and CoA. Here we...