Stephen W Ragsdale
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Explore the profile of Stephen W Ragsdale including associated specialties, affiliations and a list of published articles.
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129
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3564
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Recent Articles
1.
Ginovska B, Raugei S, Ragsdale S, Ohmer C, Sarangi R
Acc Chem Res
. 2025 Mar;
PMID: 40042658
ConspectusMethane represents 34% of U.S. energy consumption and is a major greenhouse gas related to the global carbon cycle and energy production. However, current industrial practices significantly increase atmospheric methane...
2.
Zheng K, Rush K, Date S, Johs A, Parks J, Fleischhacker A, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(47):e2408086121.
PMID: 39546574
Mercury (Hg) is a heavy metal that exhibits high biological toxicity. Monomethylmercury and dimethylmercury are neurotoxins and a significant environmental concern as they bioaccumulate and biomagnify within the aquatic food...
3.
Wang Y, Das S, Aboulhosn K, Champagne S, Gemmel P, Skinner K, et al.
J Am Chem Soc
. 2024 Aug;
146(33):23321-23329.
PMID: 39106078
Pyridoxal-5'-phosphate (PLP) and derivatives of this cofactor enable a plethora of reactions in both enzyme-mediated and free-in-solution transformations. With few exceptions in each category, such chemistry has predominantly involved two-electron...
4.
Wiley S, Griffith C, Eckert P, Mueller A, Nogle R, Simpson S, et al.
J Biol Chem
. 2024 Jun;
300(8):107503.
PMID: 38944127
One of the seven natural CO fixation pathways, the anaerobic Wood-Ljungdahl pathway (WLP) is unique in generating CO as a metabolic intermediate, operating through organometallic intermediates, and in conserving (versus...
5.
Can M, Abernathy M, Wiley S, Griffith C, James C, Xiong J, et al.
J Am Chem Soc
. 2023 Jun;
145(25):13696-13708.
PMID: 37306669
The Wood-Ljungdahl Pathway is a unique biological mechanism of carbon dioxide and carbon monoxide fixation proposed to operate through nickel-based organometallic intermediates. The most unusual steps in this metabolic cycle...
6.
Dai Y, Fleischhacker A, Liu L, Fayad S, Gunawan A, Stuehr D, et al.
Biol Chem
. 2022 Oct;
403(11-12):1043-1053.
PMID: 36302634
Heme regulatory motifs (HRMs) are found in a variety of proteins with diverse biological functions. In heme oxygenase-2 (HO2), heme binds to the HRMs and is readily transferred to the...
7.
White D, Esckilsen D, Lee S, Ragsdale S, Dyer R
J Phys Chem Lett
. 2022 Jun;
13(24):5553-5556.
PMID: 35696266
The solar conversion of CO to low carbon fuels has been heralded as a potential solution to combat the rise in greenhouse gas emissions. Here we report the first light-driven...
8.
Ohmer C, Dasgupta M, Patwardhan A, Bogacz I, Kaminsky C, Doyle M, et al.
J Inorg Biochem
. 2022 Feb;
230:111768.
PMID: 35202981
Methyl-Coenzyme M Reductase (MCR) catalyzes the biosynthesis of methane in methanogenic archaea, using a catalytic Ni-centered Cofactor F430 in its active site. It also catalyzes the reverse reaction, that is,...
9.
Hanna D, Moore C, Liu L, Yuan X, Dominic I, Fleischhacker A, et al.
J Biol Chem
. 2022 Jan;
298(2):101549.
PMID: 34973332
Heme oxygenases (HOs) detoxify heme by oxidatively degrading it into carbon monoxide, iron, and biliverdin, which is reduced to bilirubin and excreted. Humans express two isoforms of HO: the inducible...
10.
Ragsdale S
J Biol Chem
. 2021 Dec;
298(2):101511.
PMID: 34929162
Anaerobic microbes in the human gut produce beneficial and harmful compounds, as well as neutral compounds like trimethylamine, which undergoes microbial metabolism or host-catalyzed transformation into proatherogenic trimethylamine-N-oxide. Ellenbogen et ...