Per Lincoln
Overview
Explore the profile of Per Lincoln including associated specialties, affiliations and a list of published articles.
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Articles
101
Citations
994
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Recent Articles
1.
Almaqwashi A, McCauley M, Andersson J, Rouzina I, Westerlund F, Lincoln P, et al.
Biophys J
. 2025 Jan;
124(4):667-676.
PMID: 39797403
Binuclear ruthenium complexes have been investigated for potential DNA-targeted therapeutic and diagnostic applications. Studies of DNA threading intercalation, in which DNA basepairs must be broken for intercalation, have revealed means...
2.
Jabak A, Bryden N, Westerlund F, Lincoln P, McCauley M, Rouzina I, et al.
Biophys J
. 2022 Apr;
121(19):3745-3752.
PMID: 35470110
Small-molecule DNA-binding drugs have shown promising results in clinical use against many types of cancer. Understanding the molecular mechanisms of DNA binding for such small molecules can be critical in...
3.
Feng B, Sundin E, Lincoln P, Martensson A
Phys Chem Chem Phys
. 2021 Jan;
23(3):2238-2244.
PMID: 33439155
The enantiomers of a novel mononuclear ruthenium(ii) complex [Ru(phen)2bidppz]2+ with an elongated dppz moiety were synthesized. Surprisingly, the complex showed no DNA intercalating capability in an aqueous environment. However, by...
4.
Sanchez M, Rama G, Calo-Lapido R, Ucar K, Lincoln P, Vazquez Lopez M, et al.
Chem Sci
. 2019 Dec;
10(37):8668-8674.
PMID: 31803441
We report the first Ru(ii) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by...
5.
Nejat Dehkordi M, Lincoln P
J Biomol Struct Dyn
. 2019 Oct;
38(11):3318-3326.
PMID: 31588858
Linear dichroism (LD), UV-Vis and fluorescence spectroscopy were used to investigate the interaction of the Δ- and Λ-enantiomers of the two complexes of [Ru(phen) 2-phenylimidazophenanthroline] (referred to as B-complex) and...
6.
Feng B, Sosa R, Martensson A, Jiang K, Tong A, Dorfman K, et al.
Proc Natl Acad Sci U S A
. 2019 Aug;
116(35):17169-17174.
PMID: 31413203
Hydrophobic base stacking is a major contributor to DNA double-helix stability. We report the discovery of specific unstacking effects in certain semihydrophobic environments. Water-miscible ethylene glycol ethers are found to...
7.
Martensson A, Abrahamsson M, Tuite E, Lincoln P
Inorg Chem
. 2019 Jun;
58(14):9452-9459.
PMID: 31247836
The biexponential excited-state emission decay characteristic of DNA intercalated tris-bidentate dppz-based ruthenium complexes of the general form Ru(L)dppz has previously been explained by a binding model with two distinct geometry...
8.
Martensson A, Lincoln P
Phys Chem Chem Phys
. 2018 Apr;
20(16):11336-11341.
PMID: 29644359
Isothermal titration calorimetry (ITC) has been utilized to investigate the effect of methyl substituents on the intercalating dppz ligand of the enantiomers of the parent complex Ru(phen)2dppz2+ (phen = 1,10-phenanthroline;...
9.
Martensson A, Lincoln P
Phys Chem Chem Phys
. 2018 Jan;
20(12):7920-7930.
PMID: 29308462
While isothermal titration calorimetry (ITC) is widely used and sometimes referred to as the "gold standard" for quantitative measurements of biomolecular interactions, its usage has so far been limited to...
10.
Clark A, Naufer M, Westerlund F, Lincoln P, Rouzina I, Paramanathan T, et al.
Biochemistry
. 2017 Dec;
57(5):614-619.
PMID: 29243480
Molecules that bind DNA via threading intercalation show high binding affinity as well as slow dissociation kinetics, properties ideal for the development of anticancer drugs. To this end, it is...