L Marcus Wilhelmsson
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Explore the profile of L Marcus Wilhelmsson including associated specialties, affiliations and a list of published articles.
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72
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1009
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Recent Articles
1.
Sundar Rajan V, Levin S, McCauley M, Williams M, Rouzina I, Wilhelmsson L, et al.
Nucleic Acids Res
. 2024 Dec;
53(1.
PMID: 39657777
It is widely appreciated that double stranded DNA (dsDNA) is subjected to strong and dynamic mechanical forces in cells. Under increasing tension B-DNA, the most stable double-stranded (ds) form of...
2.
Pfeiffer P, Nilsson J, Gallud A, Baladi T, Le H, Bood M, et al.
Nucleic Acids Res
. 2024 Aug;
52(17):10102-10118.
PMID: 39162218
RNA and its building blocks play central roles in biology and have become increasingly important as therapeutic agents and targets. Hence, probing and understanding their dynamics in cells is important....
3.
Le H, Kuchlyan J, Baladi T, Albinsson B, Dahlen A, Wilhelmsson L
Chemistry
. 2024 Jan;
30(18):e202303539.
PMID: 38230625
Fluorescent base analogues (FBAs) have become useful tools for applications in biophysical chemistry, chemical biology, live-cell imaging, and RNA therapeutics. Herein, two synthetic routes towards a novel FBA of uracil...
4.
Sundar Rajan V, Wypijewska Del Nogal A, Levin S, Wilhelmsson L, Westerlund F
Nanoscale
. 2023 Dec;
16(2):752-764.
PMID: 38087988
The parasitic nature of the SARS-CoV-2 virus demands selective packaging of its RNA genome (gRNA) from the abundance of other nucleic acids present in infected cells. Despite increasing evidence that...
5.
Nilsson J, Benitez-Martin C, Sansom H, Pfeiffer P, Baladi T, Le H, et al.
Phys Chem Chem Phys
. 2023 Jul;
25(30):20218-20224.
PMID: 37475592
Fluorescent nucleobase analogues (FBAs) are established tools for studying oligonucleotide structure, dynamics and interactions, and have recently also emerged as an attractive option for labeling RNA-based therapeutics. A recognized drawback...
6.
Mahale S, Setia M, Prajapati B, Subhash S, Yadav M, Thankaswamy Kosalai S, et al.
Nat Commun
. 2022 Aug;
13(1):4865.
PMID: 36038571
Although antisense transcription is a widespread event in the mammalian genome, double-stranded RNA (dsRNA) formation between sense and antisense transcripts is very rare and mechanisms that control dsRNA remain unknown....
7.
Wypijewska Del Nogal A, Sundar Rajan V, Westerlund F, Wilhelmsson L
Int J Mol Sci
. 2021 Aug;
22(16).
PMID: 34445712
Pre-miRNA-377 is a hairpin-shaped regulatory RNA associated with heart failure. Here, we use single-molecule optical tweezers to unzip pre-miRNA-377 and study its stability and dynamics. We show that magnesium ions...
8.
Sundar Rajan V, Viader-Godoy X, Lin Y, Dutta U, Ritort F, Westerlund F, et al.
Phys Chem Chem Phys
. 2021 Jun;
23(26):14151-14155.
PMID: 34180930
We use mechanical unfolding of single DNA hairpins with modified bases to accurately assess intra- and intermolecular forces in nucleic acids. As expected, the modification stabilizes the hybridized hairpin, but...
9.
Nilsson J, Baladi T, Gallud A, Bazdarevic D, Lemurell M, Esbjorner E, et al.
Sci Rep
. 2021 Jun;
11(1):11365.
PMID: 34059711
To expand the antisense oligonucleotide (ASO) fluorescence labeling toolbox beyond covalent conjugation of external dyes (e.g. ATTO-, Alexa Fluor-, or cyanine dyes), we herein explore fluorescent base analogues (FBAs) as...
10.
Bood M, Wypijewska Del Nogal A, Nilsson J, Edfeldt F, Dahlen A, Lemurell M, et al.
Sci Rep
. 2021 May;
11(1):9396.
PMID: 33931703
The aberrant expression of microRNAs (miRs) has been linked to several human diseases. A promising approach for targeting these anomalies is the use of small-molecule inhibitors of miR biogenesis. These...