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Pedro P Rocha

Explore the profile of Pedro P Rocha including associated specialties, affiliations and a list of published articles. Areas
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Articles 37
Citations 1368
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Recent Articles
21.
Campos-Sanchez E, Deleyto-Seldas N, Dominguez V, Carrillo-de-Santa-Pau E, Ura K, Rocha P, et al.
Cell Rep . 2017 May; 19(8):1586-1601. PMID: 28538178
Immunodeficiency is one of the most important causes of mortality associated with Wolf-Hirschhorn syndrome (WHS), a severe rare disease originated by a deletion in chromosome 4p. The WHS candidate 1...
22.
Aranda-Orgilles B, Saldana-Meyer R, Wang E, Trompouki E, Fassl A, Lau S, et al.
Cell Stem Cell . 2016 Aug; 19(6):784-799. PMID: 27570068
Hematopoietic-specific transcription factors require coactivators to communicate with the general transcription machinery and establish transcriptional programs that maintain hematopoietic stem cell (HSC) self-renewal, promote differentiation, and prevent malignant transformation. Mediator...
23.
Jiang T, Raviram R, Snetkova V, Rocha P, Proudhon C, Badri S, et al.
Nucleic Acids Res . 2016 Jul; 44(18):8714-8725. PMID: 27439714
Use of low resolution single cell DNA FISH and population based high resolution chromosome conformation capture techniques have highlighted the importance of pairwise chromatin interactions in gene regulation. However, it...
24.
Rocha P, Raviram R, Fu Y, Kim J, Luo V, Aljoufi A, et al.
Cell Rep . 2016 Jun; 16(1):48-55. PMID: 27320916
During class switch recombination (CSR), B cells replace the Igh Cμ or δ exons with another downstream constant region exon (CH), altering the antibody isotype. CSR occurs through the introduction...
25.
Fu Y, Rocha P, Luo V, Raviram R, Deng Y, Mazzoni E, et al.
Nat Commun . 2016 May; 7:11707. PMID: 27222091
Imaging systems that allow visualization of specific loci and nuclear structures are highly relevant for investigating how organizational changes within the nucleus play a role in regulating gene expression and...
26.
Raviram R, Rocha P, Muller C, Miraldi E, Badri S, Fu Y, et al.
PLoS Comput Biol . 2016 Mar; 12(3):e1004780. PMID: 26938081
4C-Seq has proven to be a powerful technique to identify genome-wide interactions with a single locus of interest (or "bait") that can be important for gene regulation. However, analysis of...
27.
Thomas-Claudepierre A, Robert I, Rocha P, Raviram R, Schiavo E, Heyer V, et al.
J Exp Med . 2016 Feb; 213(3):303-12. PMID: 26903242
Immunoglobulin (Ig) class switch recombination (CSR) is initiated by the transcription-coupled recruitment of activation-induced cytidine deaminase (AID) to Ig switch regions (S regions). During CSR, the IgH locus undergoes dynamic...
28.
Mullenders J, Aranda-Orgilles B, Lhoumaud P, Keller M, Pae J, Wang K, et al.
J Exp Med . 2015 Oct; 212(11):1833-50. PMID: 26438359
The cohesin complex (consisting of Rad21, Smc1a, Smc3, and Stag2 proteins) is critically important for proper sister chromatid separation during mitosis. Mutations in the cohesin complex were recently identified in...
29.
Rocha P, Raviram R, Bonneau R, Skok J
Epigenomics . 2015 Jun; 7(4):523-6. PMID: 26111025
No abstract available.
30.
Narendra V, Rocha P, An D, Raviram R, Skok J, Mazzoni E, et al.
Science . 2015 Feb; 347(6225):1017-21. PMID: 25722416
Polycomb and Trithorax group proteins encode the epigenetic memory of cellular positional identity by establishing inheritable domains of repressive and active chromatin within the Hox clusters. Here we demonstrate that...