Pedro P Rocha
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Explore the profile of Pedro P Rocha including associated specialties, affiliations and a list of published articles.
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37
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1368
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Recent Articles
11.
Rhodes C, Thompson J, Mitra A, Asokumar D, Lee D, Lee D, et al.
Nat Commun
. 2022 Jul;
13(1):4196.
PMID: 35858915
A comprehensive characterization of epigenomic organization in the embryonic mouse forebrain will enhance our understanding of neurodevelopment and provide insight into mechanisms of neurological disease. Here we collected single-cell chromatin...
12.
Erdogmus S, Concepcion A, Yamashita M, Sidhu I, Tao A, Li W, et al.
Nat Commun
. 2022 Apr;
13(1):2033.
PMID: 35440113
TCR stimulation triggers Ca signals that are critical for T cell function and immunity. Several pore-forming α and auxiliary β subunits of voltage-gated Ca channels (VGCC) were reported in T...
13.
Payer L, Steranka J, Kryatova M, Grillo G, Lupien M, Rocha P, et al.
Genome Res
. 2021 Nov;
31(12):2236-2248.
PMID: 34799402
are high copy number interspersed repeats that have accumulated near genes during primate and human evolution. They are a pervasive source of structural variation in modern humans. Impacts that insertions...
14.
Beck D, Basar M, Asmar A, Thompson J, Oda H, Uehara D, et al.
Sci Adv
. 2021 Feb;
7(4).
PMID: 33523931
Reversible modification of proteins with linkage-specific ubiquitin chains is critical for intracellular signaling. Information on physiological roles and underlying mechanisms of particular ubiquitin linkages during human development are limited. Here,...
15.
Tottone L, Lancho O, Loh J, Singh A, Kimura S, Roels J, et al.
Blood Cancer Discov
. 2021 Jan;
2(1):92-109.
PMID: 33458694
Long-range oncogenic enhancers play an important role in cancer. Yet, whether similar regulation of tumor suppressor genes is relevant remains unclear. Loss of expression of PTEN is associated with the...
16.
Zuo Z, Rocha P
Trends Genet
. 2020 May;
36(6):385-387.
PMID: 32396830
Lu et al. report that the association of different repeat types with distinct gene classes goes far beyond what has previously been shown and suggest that such relationship might be...
17.
Belver L, Yang A, Albero R, Herranz D, Brundu F, Quinn S, et al.
Cancer Discov
. 2019 Sep;
9(12):1774-1791.
PMID: 31519704
Long-range enhancers govern the temporal and spatial control of gene expression; however, the mechanisms that regulate enhancer activity during normal and malignant development remain poorly understood. Here, we demonstrate a...
18.
Raviram R, Rocha P, Luo V, Swanzey E, Miraldi E, Chuong E, et al.
Genome Biol
. 2018 Dec;
19(1):216.
PMID: 30541598
Background: The organization of chromatin in the nucleus plays an essential role in gene regulation. About half of the mammalian genome comprises transposable elements. Given their repetitive nature, reads associated...
19.
Oksuz O, Narendra V, Lee C, Descostes N, LeRoy G, Raviram R, et al.
Mol Cell
. 2018 Jun;
70(6):1149-1162.e5.
PMID: 29932905
Polycomb repressive complex 2 (PRC2) maintains gene silencing by catalyzing methylation of histone H3 at lysine 27 (H3K27me2/3) within chromatin. By designing a system whereby PRC2-mediated repressive domains were collapsed...
20.
Modrek A, Golub D, Khan T, Bready D, Prado J, Bowman C, et al.
Cell Rep
. 2017 Nov;
21(5):1267-1280.
PMID: 29091765
Low-grade astrocytomas (LGAs) carry neomorphic mutations in isocitrate dehydrogenase (IDH) concurrently with P53 and ATRX loss. To model LGA formation, we introduced R132H IDH1, P53 shRNA, and ATRX shRNA into...