Pawel Krzyzek
Overview
Explore the profile of Pawel Krzyzek including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
361
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Recent Articles
1.
Krzyzek P
Int J Mol Sci
. 2024 Nov;
25(22).
PMID: 39596287
is a major pathogen associated with various gastric diseases. Despite decades of research, the treatment of remains challenging. One of the primary mechanisms contributing to failures of therapies targeting this...
2.
Krzyzek P, Dudek B, Brozyna M, Krzyzanowska B, Junka A
Microb Pathog
. 2024 Nov;
198:107121.
PMID: 39551111
Helicobacter pylori is a common Gram-negative bacterium that inhabits the human stomach and causes a variety of gastric pathologies. One of the growing concerns is its dynamic spread of antibiotic...
3.
Krzyzek P
Int J Mol Sci
. 2024 Nov;
25(21).
PMID: 39519236
Biofilms are unique, multicellular life forms that challenge our understanding of the microbial functioning. The last decades of research on biofilms have allowed us to better understand their importance in...
4.
Krzyzek P, Migdal P, Tusiewicz K, Zawadzki M, Szpot P
Front Pharmacol
. 2024 Oct;
15:1477317.
PMID: 39469629
Introduction: causes chronic gastric diseases in nearly 50% of people around the world. It is suggested that biofilm formation has a pronounced effect on the dynamic resistance spread and recurrence...
5.
Krzyzek P, Migdal P, Krzyzanowska B, Duda-Madej A
Int J Mol Sci
. 2024 Sep;
25(18).
PMID: 39337326
is one of the most common bacterial pathogens worldwide and the main etiological agent of numerous gastric diseases. The frequency of multidrug resistance of is growing and the leading factor...
6.
Zelaszczyk D, Chmiel A, Gunia-Krzyzak A, Marona H, Krzyzek P, Dworak K, et al.
Bioorg Chem
. 2024 Sep;
153:107755.
PMID: 39243741
Helicobacter pylori (H. pylori) cause chronic inflammation of the gastric mucosa which can lead to epithelial atrophy and metaplasia resulting in peptic ulcer disease and gastric cancer. The increasing resistance...
7.
Wojtys M, Maksymiuk W, Narczyk M, Bubic A, Asler I, Krzyzek P, et al.
J Enzyme Inhib Med Chem
. 2024 Aug;
39(1):2372734.
PMID: 39149761
The current therapies against gastric pathogen are ineffective in over 20% of patients. Enzymes belonging to the purine salvage pathway are considered as novel drug targets in this pathogen. Therefore,...
8.
Marinacci B, Krzyzek P, Pellegrini B, Turacchio G, Grande R
Membranes (Basel)
. 2023 Nov;
13(11).
PMID: 37999346
Outer membrane vesicles (OMVs) are spherical, lipid-based nano-structures, which are released by Gram-negative bacteria in both in vitro and in vivo conditions. The size and composition of OMVs depend on...
9.
Duda-Madej A, Kozlowska J, Baczynska D, Krzyzek P
Antibiotics (Basel)
. 2023 Jun;
12(6).
PMID: 37370395
Because of the close connection between adhesion and many vital cellular functions, the search for new compounds modulating the adhesion of bacteria belonging to the intestinal microbiota is a great...
10.
Maslanka M, Tabor W, Krzyzek P, Grabowiecka A, Berlicki L, Mucha A
Eur J Med Chem
. 2023 Jun;
257:115528.
PMID: 37290184
Catechols have been reported to be potent covalent inhibitors of ureases, and they exhibit activity by modifying cysteine residues at the entrance to enzymatic active sites. Following these principles, we...