Efflux Pumps: A Double-Edged Sword in Antibiotic Resistance and Biofilm Formation

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Nov 27

PMID 39596287

Authors

Pawel Krzyzek

Affiliations

Soon will be listed here.

Abstract

is a major pathogen associated with various gastric diseases. Despite decades of research, the treatment of remains challenging. One of the primary mechanisms contributing to failures of therapies targeting this bacterium is genetic mutations in drug target sites, although the growing body of scientific data highlights that efflux pumps may also take part in this process. Efflux pumps are proteinaceous transporters actively expelling antimicrobial agents from the interior of the targeted cells and reducing the intracellular concentration of these compounds. Considering that efflux pumps contribute to both antimicrobial resistance and biofilm formation, an in-depth understanding of their properties may constitute a cornerstone in the development of novel therapeutics against . In line with this, the aim of the current review is to describe the multitude of efflux pumps produced by and present the data describing the involvement of these proteins in tolerance and/or resistance to various classes of antimicrobial substances.

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