Pavlina Janovska
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Explore the profile of Pavlina Janovska including associated specialties, affiliations and a list of published articles.
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18
Citations
290
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Recent Articles
1.
Haag A, Nemec V, Janovska P, Bartosikova J, Adhikari B, Muller J, et al.
J Med Chem
. 2024 Dec;
68(1):506-530.
PMID: 39729064
Members of the casein kinase 1 (CK1) family have emerged as key regulators of cellular signaling and as potential drug targets. Functional annotation of the 7 human isoforms would benefit...
2.
Kurucova T, Reblova K, Janovska P, Porc J, Navrkalova V, Pavlova S, et al.
Mol Oncol
. 2024 May;
18(10):2541-2553.
PMID: 38770541
Early identification of resistant cancer cells is currently a major challenge, as their expansion leads to refractoriness. To capture the dynamics of these cells, we made a comprehensive analysis of...
3.
Nemec V, Khirsariya P, Janovska P, Moyano P, Maier L, Prochazkova P, et al.
Angew Chem Int Ed Engl
. 2023 Jan;
62(11):e202217532.
PMID: 36625768
Casein kinases 1 (CK1) are key signaling molecules that have emerged recently as attractive therapeutic targets in particular for the treatment of hematological malignancies. Herein, we report the identification of...
4.
cada S, Vondalova Blanarova O, Gomoryova K, Mikulova A, Bacovska P, Zezula N, et al.
Front Cell Dev Biol
. 2022 Dec;
10:911966.
PMID: 36561363
The migratory properties of leukemic cells are commonly associated with their pathological potential and can significantly affect the disease progression. While the research in immunopathology mostly employed powerful indirect methods...
5.
Poppova L, Pavlova S, Gonzalez B, Kotaskova J, Plevova K, Dumbovic G, et al.
Epigenetics
. 2022 Mar;
17(12):1628-1635.
PMID: 35333703
Genome methylation profiles define naïve-like (n-CLL), memory-like (m-CLL), and intermediate (i-CLL) subsets of chronic lymphocytic leukaemia (CLL). The profiles can be easily determined by the analysis of the five-CpG signature....
6.
Dave Z, Vondalova Blanarova O, cada S, Janovska P, Zezula N, Behal M, et al.
Front Cell Dev Biol
. 2022 Mar;
10:838871.
PMID: 35295854
Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are malignancies characterized by the dependence on B-cell receptor (BCR) signaling and by the high expression of ROR1, the cell surface...
7.
Janovska P, Normant E, Miskin H, Bryja V
Int J Mol Sci
. 2020 Dec;
21(23).
PMID: 33261128
The casein kinase 1 enzymes (CK1) form a family of serine/threonine kinases with seven CK1 isoforms identified in humans. The most important substrates of CK1 kinases are proteins that act...
8.
Kozlova V, Ledererova A, Ladungova A, Peschelova H, Janovska P, Slusarczyk A, et al.
PLoS One
. 2020 Mar;
15(3):e0229170.
PMID: 32210425
Surface protein CD20 serves as the critical target of immunotherapy in various B-cell malignancies for decades, however its biological function and regulation remain largely elusive. Better understanding of CD20 function...
9.
Janovska P, Verner J, Kohoutek J, Bryjova L, Gregorova M, Dzimkova M, et al.
Blood
. 2018 Jan;
131(11):1206-1218.
PMID: 29317454
Casein kinase 1δ/ε (CK1δ/ε) is a key component of noncanonical Wnt signaling pathways, which were shown previously to drive pathogenesis of chronic lymphocytic leukemia (CLL). In this study, we investigated...
10.
Plesingerova H, Janovska P, Mishra A, Smyckova L, Poppova L, Libra A, et al.
Haematologica
. 2017 Nov;
103(2):313-324.
PMID: 29122990
Chronic lymphocytic leukemia is a disease with up-regulated expression of the transmembrane tyrosine-protein kinase ROR1, a member of the Wnt/planar cell polarity pathway. In this study, we identified COBLL1 as...