Pavlina Haskova
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Explore the profile of Pavlina Haskova including associated specialties, affiliations and a list of published articles.
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25
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259
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Recent Articles
1.
Haskova P, Applova L, Jansova H, Homola P, Franz K, Vavrova K, et al.
Sci Rep
. 2022 Jun;
12(1):9765.
PMID: 35697900
Labile redox-active iron ions have been implicated in various neurodegenerative disorders, including the Parkinson's disease (PD). Iron chelation has been successfully used in clinical practice to manage iron overload in...
2.
Hruskova K, Potuckova E, Opalka L, Hergeselova T, Haskova P, Kovarikova P, et al.
Chem Res Toxicol
. 2018 May;
31(6):435-446.
PMID: 29766723
Aroylhydrazone iron chelators such as salicylaldehyde isonicotinoyl hydrazone (SIH) protect various cells against oxidative injury and display antineoplastic activities. Previous studies have shown that a nitro-substituted hydrazone, namely, NHAPI, displayed...
3.
Novotna E, Waisser K, Kunes J, Palat K, Skalova L, Szotakova B, et al.
Arch Pharm (Weinheim)
. 2017 Jun;
350(8).
PMID: 28635184
A series of benzaldehyde and salicylaldehyde-S-benzylisothiosemicarbazones was synthesized and tested against 12 different strains of mycobacteria, Gram-positive and Gram-negative bacteria, and the significant selectivity toward mycobacteria was proved. Twenty-eight derivatives...
4.
Haskova P, Jansova H, Bures J, Machacek M, Jirkovska A, Franz K, et al.
Toxicology
. 2016 Oct;
371:17-28.
PMID: 27744045
Catecholamines may undergo iron-promoted oxidation resulting in formation of reactive intermediates (aminochromes) capable of redox cycling and reactive oxygen species (ROS) formation. Both of them induce oxidative stress resulting in...
5.
Hruskova K, Potuckova E, Hergeselova T, Liptakova L, Haskova P, Mingas P, et al.
Eur J Med Chem
. 2016 May;
120:97-110.
PMID: 27187862
Aroylhydrazones such as salicylaldehyde isonicotinoyl hydrazone (SIH) are tridentate iron chelators that may possess antioxidant and/or antineoplastic activities. Their main drawback, their low stability in plasma, has recently been partially...
6.
Filipsky T, Riha M, Haskova P, Pilarova V, Novakova L, Semecky V, et al.
Redox Rep
. 2016 Apr;
22(2):78-90.
PMID: 27077454
Objectives: Rutin, quercetin-3-O-rutinoside, a natural flavonol glycoside, has shown various in vitro benefits with potential use treating human diseases, especially cardiovascular system disorders. Antioxidant properties are assumed to underlie the...
7.
Jansova H, Bures J, Machacek M, Haskova P, Jirkovska A, Roh J, et al.
Toxicology
. 2016 Apr;
350-352:15-24.
PMID: 27046792
Free cellular iron catalyzes the formation of toxic hydroxyl radicals and therefore chelation of iron could be a promising therapeutic approach in pathological states associated with oxidative stress. Salicylaldehyde isonicotinoyl...
8.
Riha M, Haskova P, Martin J, Filipsky T, Vanova K, Vavrova J, et al.
Oxid Med Cell Longev
. 2016 Jan;
2016:5213532.
PMID: 26788248
Iron and copper release participates in the myocardial injury under ischemic conditions and hence protection might be achieved by iron chelators. Data on copper chelation are, however, sparse. The effect...
9.
Potuckova E, Roh J, Machacek M, Sahni S, Stariat J, Sestak V, et al.
PLoS One
. 2015 Oct;
10(10):e0139929.
PMID: 26460540
Cancer cells have a high iron requirement and many experimental studies, as well as clinical trials, have demonstrated that iron chelators are potential anti-cancer agents. The ligand, 2-benzoylpyridine 4-ethyl-3-thiosemicarbazone (Bp4eT),...
10.
Arel-Dubeau A, Longpre F, Bournival J, Tremblay C, Demers-Lamarche J, Haskova P, et al.
Oxid Med Cell Longev
. 2015 Jan;
2014:425496.
PMID: 25574337
Natural molecules are under intensive study for their potential as preventive and/or adjuvant therapies for neurodegenerative disorders such as Parkinson's disease (PD). We evaluated the neuroprotective potential of cucurbitacin E...