Katerina Hruskova
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Explore the profile of Katerina Hruskova including associated specialties, affiliations and a list of published articles.
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9
Citations
55
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Recent Articles
1.
Hruskova K, Potuckova E, Opalka L, Hergeselova T, Haskova P, Kovarikova P, et al.
Chem Res Toxicol
. 2018 May;
31(6):435-446.
PMID: 29766723
Aroylhydrazone iron chelators such as salicylaldehyde isonicotinoyl hydrazone (SIH) protect various cells against oxidative injury and display antineoplastic activities. Previous studies have shown that a nitro-substituted hydrazone, namely, NHAPI, displayed...
2.
Hruskova K, Potuckova E, Hergeselova T, Liptakova L, Haskova P, Mingas P, et al.
Eur J Med Chem
. 2016 May;
120:97-110.
PMID: 27187862
Aroylhydrazones such as salicylaldehyde isonicotinoyl hydrazone (SIH) are tridentate iron chelators that may possess antioxidant and/or antineoplastic activities. Their main drawback, their low stability in plasma, has recently been partially...
3.
Potuckova E, Hruskova K, Bures J, Kovarikova P, Spirkova I, Pravdikova K, et al.
PLoS One
. 2014 Nov;
9(11):e112059.
PMID: 25393531
Salicylaldehyde isonicotinoyl hydrazone (SIH) is a lipophilic, tridentate iron chelator with marked anti-oxidant and modest cytotoxic activity against neoplastic cells. However, it has poor stability in an aqueous environment due...
4.
Smrckova P, Horsky J, Sarka E, Kolacek J, Netopilik M, Walterova Z, et al.
Carbohydr Polym
. 2013 Aug;
98(1):43-9.
PMID: 23987315
Wheat B-starch was hydrolysed by α-amylase "Liquozyme supra" from Bacillus licheniformis at 90 °C and pH 7. After 2 h, the dextrose equivalent was 18; according to size exclusion chromatography,...
5.
Mackova E, Hruskova K, Bendova P, Vavrova A, Jansova H, Haskova P, et al.
Chem Biol Interact
. 2012 Apr;
197(2-3):69-79.
PMID: 22521999
Salicylaldehyde isonicotinoyl hydrazone (SIH) is a lipophilic, orally-active tridentate iron chelator providing both effective protection against various types of oxidative stress-induced cellular injury and anticancer action. However, the major limitation...
6.
Haskova P, Koubkova L, Vavrova A, Mackova E, Hruskova K, Kovarikova P, et al.
Toxicology
. 2011 Aug;
289(2-3):122-31.
PMID: 21864640
Catecholamines are stress hormones and sympathetic neurotransmitters essential for control of cardiac function and metabolism. However, pathologically increased catecholamine levels may be cardiotoxic by mechanism that includes iron-catalyzed formation of...
7.
Hruskova K, Kovarikova P, Bendova P, Haskova P, Mackova E, Stariat J, et al.
Chem Res Toxicol
. 2011 Jan;
24(3):290-302.
PMID: 21214215
Oxidative stress is known to contribute to a number of cardiovascular pathologies. Free intracellular iron ions participate in the Fenton reaction and therefore substantially contribute to the formation of highly...
8.
Kovarikova P, Stariat J, Klimes J, Hruskova K, Vavrova K
J Chromatogr A
. 2010 Dec;
1218(3):416-26.
PMID: 21168142
This paper presents a systematic study of the retention behavior of a model bisdioxopiperazine drug, dexrazoxane (DEX) and its three polar metabolites (two single open-ring intermediates-B and C and an...
9.
Kovarikova P, Vavrova K, Tomalova K, Schongut M, Hruskova K, Haskova P, et al.
J Pharm Biomed Anal
. 2008 Jan;
48(2):295-302.
PMID: 18222619
Salicylaldehyde isonicotinoyl hydrazone (SIH) is an iron-chelating aromatic hydrazone with promising pharmacological properties. However, it suffers from relatively short biological half-life. Hence, two novel derivates of SIH, HAP-INH and HPP-INH...