Pavithran T Ravindran
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Explore the profile of Pavithran T Ravindran including associated specialties, affiliations and a list of published articles.
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12
Citations
282
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Recent Articles
1.
Piraner D, Abedi M, Duran Gonzalez M, Chazin-Gray A, Lin A, Zhu I, et al.
Nature
. 2024 Nov;
638(8051):805-813.
PMID: 39542025
Despite recent advances in mammalian synthetic biology, there remains a lack of modular synthetic receptors that can robustly respond to soluble ligands and, in turn, activate bespoke cellular functions. Such...
2.
Li J, Ravindran P, OFarrell A, Busch G, Boe R, Niu Z, et al.
bioRxiv
. 2024 Aug;
PMID: 39091739
Cellular responses to environmental stimuli are typically thought to be governed by genetically encoded programs. We demonstrate that melanoma cells can form and maintain cellular memories during the acquisition of...
3.
Goyal Y, Busch G, Pillai M, Li J, Boe R, Grody E, et al.
Nature
. 2023 Jul;
620(7974):651-659.
PMID: 37468627
Even among genetically identical cancer cells, resistance to therapy frequently emerges from a small subset of those cells. Molecular differences in rare individual cells in the initial population enable certain...
4.
Palmer M, Nerger B, Goodwin K, Sudhakar A, Lemke S, Ravindran P, et al.
Sci Adv
. 2021 Dec;
7(52):eabk0161.
PMID: 34936466
The function of the lung is closely coupled to its structural anatomy, which varies greatly across vertebrates. Although architecturally simple, a complex pattern of airflow is thought to be achieved...
5.
Ravindran P, McFann S, Thornton R, Toettcher J
Cell Syst
. 2021 Nov;
13(2):131-142.e13.
PMID: 34739875
Cells employ intracellular signaling pathways to sense and respond to changes in their external environment. In recent years, live-cell biosensors have revealed complex pulsatile dynamics in many pathways, but studies...
6.
Hussain S, Majumdar R, Moore G, Narang H, Buechelmaier E, Bazil M, et al.
Nucleic Acids Res
. 2021 Apr;
49(13):e74.
PMID: 33877327
Double strand break (DSB) repair primarily occurs through 3 pathways: non-homologous end-joining (NHEJ), alternative end-joining (Alt-EJ), and homologous recombination (HR). Typical methods to measure pathway usage include integrated cassette reporter...
7.
Iuliano J, Tolentino Collado J, Gil A, Ravindran P, Lukacs A, Shin S, et al.
ACS Chem Biol
. 2020 Sep;
15(10):2752-2765.
PMID: 32880430
Light-activated protein domains provide a convenient, modular, and genetically encodable sensor for optogenetics and optobiology. Although these domains have now been deployed in numerous systems, the precise mechanism of photoactivation...
8.
Ravindran P, Wilson M, Jena S, Toettcher J
Commun Biol
. 2020 Aug;
3(1):436.
PMID: 32792645
Many cell- and tissue-level functions are coordinated by intracellular signaling pathways that trigger the expression of context-specific target genes. Yet the input-output relationships that link pathways to the genes they...
9.
Gil A, Carrasco-Lopez C, Zhu L, Zhao E, Ravindran P, Wilson M, et al.
Nat Commun
. 2020 Aug;
11(1):4044.
PMID: 32792536
A growing number of optogenetic tools have been developed to reversibly control binding between two engineered protein domains. In contrast, relatively few tools confer light-switchable binding to a generic target...
10.
Leeman J, Li Y, Bell A, Hussain S, Majumdar R, Rong-Mullins X, et al.
Proc Natl Acad Sci U S A
. 2019 Oct;
116(43):21573-21579.
PMID: 31591214
Squamous cell carcinomas (SCCs) arising from aerodigestive or anogenital epithelium that are associated with the human papillomavirus (HPV) are far more readily cured with radiation therapy than HPV-negative SCCs. The...