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Paula M Checchi

Explore the profile of Paula M Checchi including associated specialties, affiliations and a list of published articles. Areas
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Articles 12
Citations 241
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Recent Articles
1.
Ananthaswamy D, Funes K, Borges T, Roques S, Fassnacht N, Jamal S, et al.
bioRxiv . 2024 Sep; PMID: 39314477
Organisms rely on coordinated networks of DNA repair pathways to protect genomes against toxic double-strand breaks (DSBs), particularly in germ cells. All repair mechanisms must successfully negotiate the local chromatin...
2.
Bradford B, Briand N, Fassnacht N, Gervasio E, Nowakowski A, FitzGibbon T, et al.
Genetics . 2020 Dec; 216(4):879-890. PMID: 33268390
Environmental toxicants are chemicals that negatively affect human health. Although there are numerous ways to limit exposure, the ubiquitous nature of certain environmental toxicants makes it impossible to avoid them...
3.
Bradford B, Whidden E, Gervasio E, Checchi P, Raley-Susman K
PLoS One . 2020 Sep; 15(9):e0238637. PMID: 32903270
Neonicotinoids, a class of insecticides structurally similar to nicotine that target biting and sucking insects, are the most widely used insecticides today, in part due to their supposed low toxicity...
4.
Li Q, Saito T, Martinez-Garcia M, Deshong A, Nadarajan S, Lawrence K, et al.
PLoS Genet . 2018 Nov; 14(11):e1007701. PMID: 30383767
Breast cancer susceptibility gene 1 (BRCA1) and binding partner BRCA1-associated RING domain protein 1 (BARD1) form an essential E3 ubiquitin ligase important for DNA damage repair and homologous recombination. The...
5.
Turcotte C, Sloat S, Rigothi J, Rosenkranse E, Northrup A, Andrews N, et al.
Genetics . 2018 Jan; 208(3):991-1007. PMID: 29339410
Meiotic recombination depends upon the tightly coordinated regulation of chromosome dynamics and is essential for the production of haploid gametes. Central to this process is the formation and repair of...
6.
Turcotte C, Andrews N, Sloat S, Checchi P
Genetics . 2017 Jan; 204(3):883-891. PMID: 28114101
The mechanisms cells use to maintain genetic fidelity via DNA repair and the accuracy of these processes have garnered interest from scientists engaged in basic research to clinicians seeking improved...
7.
Checchi P, Lawrence K, Van M, Larson B, Engebrecht J
Genetics . 2014 Jun; 197(2):543-60. PMID: 24939994
During meiosis, accurate chromosome segregation relies on homology to mediate chromosome pairing, synapsis, and crossover recombination. Crossovers are dependent upon formation and repair of double-strand breaks (DSBs) by homologous recombination...
8.
Checchi P, Engebrecht J
Mol Reprod Dev . 2011 Nov; 78(9):623-32. PMID: 22113949
Accurate chromosome segregation during meiosis relies on homology between the maternal and paternal chromosomes. Yet by definition, sex chromosomes of the heterogametic sex lack a homologous partner. Recent studies in...
9.
Checchi P, Engebrecht J
PLoS Genet . 2011 Sep; 7(9):e1002267. PMID: 21909284
Meiosis is a specialized form of cellular division that results in the precise halving of the genome to produce gametes for sexual reproduction. Checkpoints function during meiosis to detect errors...
10.
Furuhashi H, Takasaki T, Rechtsteiner A, Li T, Kimura H, Checchi P, et al.
Epigenetics Chromatin . 2010 Aug; 3(1):15. PMID: 20704745
Background: The processes through which the germline maintains its continuity across generations has long been the focus of biological research. Recent studies have suggested that germline continuity can involve epigenetic...