Gene Therapy Approaches to Human Immunodeficiency Virus and Other Infectious Diseases

Overview

Journal Hematol Oncol Clin North Am

Specialties Hematology
Oncology

Date 2017 Sep 13

PMID 28895854

Citations 6

Authors

Geoffrey L Rogers

Paula M Cannon

Affiliations

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Abstract

Advances in gene therapy technologies, particularly in gene editing, are suggesting new avenues for the treatment of human immunodeficiency virus and other infectious diseases. This article outlines recent developments in antiviral gene therapies, including those based on the disruption of entry receptors or that target viral genomes using targeted nucleases, such as the CRISPR/Cas9 system. In addition, new ways to express circulating antiviral factors, such as antibodies, and approaches to harness and engineer the immune system to provide an antiviral effect that is not naturally achieved are described.

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Reduce and Control: A Combinatorial Strategy for Achieving Sustained HIV Remissions in the Absence of Antiretroviral Therapy.

Schwarzer R, Gramatica A, Greene W Viruses. 2020; 12(2).

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Development of Lentiviral Vectors for HIV-1 Gene Therapy with Vif-Resistant APOBEC3G.

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Lampi Y, Van Looveren D, Vranckx L, Thiry I, Bornschein S, Debyser Z Sci Rep. 2019; 9(1):2389.

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Surface-Engineered Lentiviral Vectors for Selective Gene Transfer into Subtypes of Lymphocytes.

Frank A, Buchholz C Mol Ther Methods Clin Dev. 2018; 12:19-31.

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