Paula Desplats
Overview
Explore the profile of Paula Desplats including associated specialties, affiliations and a list of published articles.
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44
Citations
3195
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Recent Articles
1.
Spencer B, Emadi S, Desplats P, Eleuteri S, Michael S, Kosberg K, et al.
Mol Ther
. 2025 Feb;
33(3):1302.
PMID: 39900036
No abstract available.
2.
Roos M, Bunga S, Tan A, Maissy E, Skola D, Richter A, et al.
bioRxiv
. 2025 Jan;
PMID: 39868335
Importance: Sequencing total RNA from microbiome samples is seriously impaired by the overwhelming proportion of rRNA to mRNA content. As much as 99% of sequencing reads can be assigned to...
3.
Whittaker D, Akhmetova L, Carlin D, Romero H, Welsh D, Colwell C, et al.
Cell Metab
. 2023 Aug;
35(10):1704-1721.e6.
PMID: 37607543
Circadian disruptions impact nearly all people with Alzheimer's disease (AD), emphasizing both their potential role in pathology and the critical need to investigate the therapeutic potential of circadian-modulating interventions. Here,...
4.
Hopfner F, Tietz A, Ruf V, Ross O, Koga S, Dickson D, et al.
Mov Disord
. 2022 Aug;
37(10):2110-2121.
PMID: 35997131
Background: Multiple System Atrophy is a rare neurodegenerative disease with alpha-synuclein aggregation in glial cytoplasmic inclusions and either predominant olivopontocerebellar atrophy or striatonigral degeneration, leading to dysautonomia, parkinsonism, and cerebellar...
5.
Nasamran C, Sachan A, Mott J, Kuras Y, Scherzer C, Study H, et al.
Alzheimers Dement (Amst)
. 2021 Mar;
13(1):e12156.
PMID: 33665346
Introduction: Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are characterized by cognitive alterations, visual hallucinations, and motor impairment. Diagnosis is based on type and timing of clinical...
6.
Gutierrez A, Corey-Bloom J, Thomas E, Desplats P
Front Mol Neurosci
. 2020 Feb;
12:335.
PMID: 32038165
Huntington's disease (HD) is an autosomal-dominant neurodegenerative movement disorder that presents with prominent cognitive and psychiatric dysfunction. Brain-derived neurotrophic factor (BDNF) plays an important role in the pathophysiology of HD,...
7.
Haspel J, Anafi R, Brown M, Cermakian N, Depner C, Desplats P, et al.
JCI Insight
. 2020 Jan;
5(1).
PMID: 31941836
Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune system homeostasis. Both innate and adaptive immune responses - ranging from leukocyte mobilization, trafficking, and chemotaxis to...
8.
Desplats P, Gutierrez A, Antonelli M, Frasch M
Neurosci Biobehav Rev
. 2019 Nov;
117:232-242.
PMID: 31703966
We review evidence supporting the role of early life programming in the susceptibility for adult neurodegenerative diseases while highlighting questions and proposing avenues for future research to advance our understanding...
9.
Kim T, Valera E, Desplats P
Mol Neurobiol
. 2019 Apr;
56(10):7003-7021.
PMID: 30968343
Multiple systems atrophy (MSA) is a rare neurodegenerative disorder characterized by the accumulation of α-synuclein in glial cells and neurodegeneration in the striatum, substantia nigra, and cerebellum. Aberrant miRNA regulation...
10.
Henderson-Smith A, Fisch K, Hua J, Liu G, Ricciardelli E, Jepsen K, et al.
Epigenetics
. 2019 Mar;
14(4):365-382.
PMID: 30871403
Parkinson's Disease (PD) is a common neurodegenerative disorder currently diagnosed based on the presentation of characteristic movement symptoms. Unfortunately, patients exhibiting these symptoms have already undergone significant dopaminergic neuronal loss....