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Brian Spencer

Explore the profile of Brian Spencer including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 97
Citations 9075
Followers 0
Related Specialties
Neurology
Science
Biochemistry
Top 10 Co-Authors
Eliezer Masliah
Edward Rockenstein
Anthony Adame
Michael Mante
Christina Patrick
Paula Desplats
Robert A Rissman
Leslie Crews
Tatiana Prokaeva
Lawreen H Connors
Published In
PLoS One
Amyloid
J Neurosci
Neurobiol Dis
Mol Ther
Affiliations
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Recent Articles
1.
Retraction Notice to: Lentivirus Mediated Delivery of Neurosin Promotes Clearance of Wild-type α-Synuclein and Reduces the Pathology in an α-Synuclein Model of LBD
Spencer B, Michael S, Shen J, Kosberg K, Rockenstein E, Patrick C, et al.
Mol Ther . 2025 Feb; 33(3):1301. PMID: 39909031
No abstract available.
2.
Retraction Notice to: ESCRT-mediated Uptake and Degradation of Brain-targeted α-synuclein Single Chain Antibody Attenuates Neuronal Degeneration In Vivo
Spencer B, Emadi S, Desplats P, Eleuteri S, Michael S, Kosberg K, et al.
Mol Ther . 2025 Feb; 33(3):1302. PMID: 39900036
No abstract available.
3.
Corrigendum to "Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy" Exp Neurol. 2012 April; 234(2): 405-416
Ubhi K, Inglis C, Mante M, Patrick C, Adame A, Spencer B, et al.
Exp Neurol . 2024 Jun; 379:114873. PMID: 38937165
No abstract available.
4.
Correction: Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models
Blurton-Jones M, Spencer B, Michael S, Castello N, Agazaryan A, Davis J, et al.
Stem Cell Res Ther . 2024 Mar; 15(1):88. PMID: 38523285
No abstract available.
5.
Corrigendum to " Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy Body Disease" [Neurobiology of Disease127 (2019) 163-177]
Spencer B, Trinh I, Rockenstein E, Mante M, Florio J, Adame A, et al.
Neurobiol Dis . 2024 Jan; 191:106397. PMID: 38216383
No abstract available.
6.
Neurofilament light chain kinetics as a biomarker for polyneuropathy in V122I hereditary transthyretin amyloidosis
Lau K, Prokaeva T, Zheng L, Doros G, Kaku M, Spencer B, et al.
Amyloid . 2023 Dec; 31(2):150-152. PMID: 38073425
No abstract available.
7.
Novel systemic delivery of a peptide-conjugated antisense oligonucleotide to reduce α-synuclein in a mouse model of Alzheimer's disease
Leitao A, Ahammad R, Spencer B, Wu C, Masliah E, Rissman R
Neurobiol Dis . 2023 Sep; 186:106285. PMID: 37690676
Neurodegenerative disorders of aging are characterized by the progressive accumulation of proteins such as α-synuclein (α-syn) and amyloid beta (Aβ). Misfolded and aggregated α-syn has been implicated in neurological disorders...
8.
Hippocampal Reduction of α-Synuclein via RNA Interference Improves Neuropathology in Alzheimer's Disease Mice
Leitao A, Spencer B, Sarsoza F, Ngolab J, Amalraj J, Masliah E, et al.
J Alzheimers Dis . 2023 Jul; 95(1):349-361. PMID: 37522208
Background: Alzheimer's disease (AD) cases are often characterized by the pathological accumulation of α-synuclein (α-syn) in addition to amyloid-β (Aβ) and tau hallmarks. The role of α-syn has been extensively...
9.
Hereditary gelsolin amyloidosis: a rare cause of cranial, peripheral and autonomic neuropathies linked to D187N and Y447H substitutions
Mendelson L, Prokaeva T, Lau K, Sanchorawala V, McCausland K, Spencer B, et al.
Amyloid . 2023 May; 30(4):357-363. PMID: 37140928
Introduction: Hereditary gelsolin (AGel) amyloidosis is a systemic disease that is characterised by neurologic, ophthalmologic, dermatologic, and other organ involvements. We describe the clinical features with a focus on neurological...
10.
Reverses Motor Deficits and Reduces Accumulation of Human α-Synuclein Protein in Two Different Parkinson's Disease Animal Models
Dutta A, Armstrong C, Luo D, Das B, Spencer B, Rissman R
ACS Chem Neurosci . 2023 Feb; 14(5):885-896. PMID: 36749600
Aggregation of misfolded α-synuclein (α-syn) protein in the periphery and central nervous system (CNS) gives rise to a group of disorders, which are labeled collectively as synucleinopathies. These clinically distinct...