Bissan Al-Lazikani
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Explore the profile of Bissan Al-Lazikani including associated specialties, affiliations and a list of published articles.
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64
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6272
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Recent Articles
1.
George S, Lynn C, Stankunaite R, Hughes D, Sauer C, Chalker J, et al.
Cancer Discov
. 2024 Dec;
PMID: 39693475
We profiled a large heterogenous cohort of matched diagnostic-relapse tumour tissue and paired plasma-derived cell free DNA (cfDNA) from patients with relapsed and progressive solid tumours of childhood. Tissue and...
2.
Sanfelice D, Antolin A, Crisp A, Chen Y, Bellenie B, Brennan P, et al.
Nucleic Acids Res
. 2024 Nov;
53(D1):D1663-D1669.
PMID: 39558166
The Chemical Probes Portal (www.chemicalprobes.org) is a free, public resource, based on expert-reviews, that supports the assessment, selection and use of small-molecule compounds that qualify as chemical probes. These high-quality...
3.
Gingrich P, Chitsazi R, Biswas A, Jiang C, Zhao L, Tym J, et al.
Nucleic Acids Res
. 2024 Nov;
53(D1):D1287-D1294.
PMID: 39535036
canSAR (https://cansar.ai) continues to serve as the largest publicly available platform for cancer-focused drug discovery and translational research. It integrates multidisciplinary data from disparate and otherwise siloed public data sources...
4.
James N, Tannock I, Ndow J, Feng F, Gillessen S, Ali S, et al.
Lancet
. 2024 Apr;
403(10437):1683-1722.
PMID: 38583453
No abstract available.
5.
Gilbertson R, Behjati S, Bottcher A, Bronner M, Burridge M, Clausing H, et al.
Cancer Discov
. 2024 Apr;
14(4):663-668.
PMID: 38571421
We are building the world's first Virtual Child-a computer model of normal and cancerous human development at the level of each individual cell. The Virtual Child will "develop cancer" that...
6.
Neeb A, Figueiredo I, Bogdan D, Cato L, Stober J, Jimenez-Vacas J, et al.
Mol Cancer Ther
. 2024 Feb;
23(6):791-808.
PMID: 38412481
Therapies that abrogate persistent androgen receptor (AR) signaling in castration-resistant prostate cancer (CRPC) remain an unmet clinical need. The N-terminal domain of the AR that drives transcriptional activity in CRPC...
7.
Al-Tashi Q, Saad M, Sheshadri A, Wu C, Chang J, Al-Lazikani B, et al.
Patterns (N Y)
. 2023 Aug;
4(8):100777.
PMID: 37602223
Survival models exist to study relationships between biomarkers and treatment effects. Deep learning-powered survival models supersede the classical Cox proportional hazards (CoxPH) model, but substantial performance drops were observed on...
8.
di Micco P, Antolin A, Mitsopoulos C, Villasclaras-Fernandez E, Sanfelice D, Dolciami D, et al.
Nucleic Acids Res
. 2023 Jan;
51(D1):D1212-D1219.
PMID: 36624665
canSAR (https://cansar.ai) is the largest public cancer drug discovery and translational research knowledgebase. Now hosted in its new home at MD Anderson Cancer Center, canSAR integrates billions of experimental measurements...
9.
Antolin A, Sanfelice D, Crisp A, Villasclaras Fernandez E, Mica I, Chen Y, et al.
Nucleic Acids Res
. 2022 Oct;
51(D1):D1492-D1502.
PMID: 36268860
We describe the Chemical Probes Portal (https://www.chemicalprobes.org/), an expert review-based public resource to empower chemical probe assessment, selection and use. Chemical probes are high-quality small-molecule reagents, often inhibitors, that are...
10.
Dolciami D, Villasclaras-Fernandez E, Kannas C, Meniconi M, Al-Lazikani B, Antolin A
J Cheminform
. 2022 Jun;
14(1):28.
PMID: 35643512
Background: Integration of medicinal chemistry data from numerous public resources is an increasingly important part of academic drug discovery and translational research because it can bring a wealth of important...