Paul Warrener
Overview
Explore the profile of Paul Warrener including associated specialties, affiliations and a list of published articles.
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27
Citations
1069
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0
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Recent Articles
1.
Gopalakrishnan V, Sparklin B, Kim J, Bouquet J, Kehl M, Kenny T, et al.
Respir Res
. 2025 Jan;
26(1):45.
PMID: 39885466
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease characterized by airway obstruction and inflammation. Non-typeable Haemophilus influenzae (NTHi) lung infections are common in COPD, promoting frequent exacerbations and...
2.
Berry S, Rust S, Irving L, Scott J, Weinert L, Dougan G, et al.
Microbiol Spectr
. 2024 Jun;
12(8):e0040024.
PMID: 38940542
We used phage display, antibody engineering, and high-throughput assays to identify antibody-accessible targets of . We report the discovery of monoclonal antibodies (mAbs) binding to type 3 fimbrial proteins, including...
3.
Long M, Gilmour A, Kehl M, Tabor D, Keller A, Warrener P, et al.
Am J Respir Crit Care Med
. 2024 May;
210(1):35-46.
PMID: 38754132
infection is associated with worse outcomes in bronchiectasis. Impaired neutrophil antimicrobial responses contribute to bacterial persistence. Gremubamab is a bivalent, bispecific monoclonal antibody targeting Psl exopolysaccharide and the type 3...
4.
Berry S, Rust S, Caceres C, Irving L, Scott J, Tabor D, et al.
MAbs
. 2021 Dec;
14(1):2006123.
PMID: 34923908
The increasing global occurrence of recalcitrant multi-drug resistant infections warrants the investigation of alternative therapy options, such as the use of monoclonal antibodies (mAbs). We used a target-agnostic phage display...
5.
Gopalakrishnan V, Dozier E, Glover M, Novick S, Ford M, Morehouse C, et al.
Microorganisms
. 2021 Jul;
9(7).
PMID: 34209573
The gut microbiota has emerged as a key mediator of human physiology, and germ-free mice have been essential in demonstrating a role for the microbiome in disease. Preclinical models using...
6.
Jones-Nelson O, Tovchigrechko A, Glover M, Fernandes F, Rangaswamy U, Liu H, et al.
Antimicrob Agents Chemother
. 2020 Mar;
64(5).
PMID: 32152087
Antibiotics revolutionized the treatment of infectious diseases; however, it is now clear that broad-spectrum antibiotics alter the composition and function of the host's microbiome. The microbiome plays a key role...
7.
Boland M, Oro D, Tolbol K, Thrane S, Nielsen J, Cohen T, et al.
World J Gastroenterol
. 2019 Sep;
25(33):4904-4920.
PMID: 31543682
Background: The trans-fat containing AMLN (amylin liver non-alcoholic steatohepatitis, NASH) diet has been extensively validated in C57BL/6J mice with or without the Lep/Lep () mutation in the leptin gene for...
8.
Thanabalasuriar A, Scott B, Peiseler M, Willson M, Zeng Z, Warrener P, et al.
Cell Host Microbe
. 2019 Apr;
25(4):526-536.e4.
PMID: 30930127
Bacterial biofilm infections are difficult to eradicate because of antibiotic insusceptibility and high recurrence rates. Biofilm formation by Pseudomonas aeruginosa, a leading cause of bacterial keratitis, is facilitated by the...
9.
Jones-Nelson O, Hilliard J, DiGiandomenico A, Warrener P, Alfaro A, Cheng L, et al.
Am J Respir Cell Mol Biol
. 2018 Aug;
59(6):745-756.
PMID: 30109945
Pseudomonas aeruginosa and Klebsiella pneumoniae are two common gram-negative pathogens that are associated with bacterial pneumonia and can often be isolated from the same patient. We used a mixed-pathogen pneumonia...
10.
Pennini M, De Marco A, Pelletier M, Bonnell J, Cvitkovic R, Beltramello M, et al.
Nat Commun
. 2017 Dec;
8(1):1991.
PMID: 29222409
Emerging multidrug-resistant bacteria are a challenge for modern medicine, but how these pathogens are so successful is not fully understood. Robust antibacterial vaccines have prevented and reduced resistance suggesting a...