Paul W Needs
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Explore the profile of Paul W Needs including associated specialties, affiliations and a list of published articles.
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52
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1020
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Recent Articles
1.
Kaci H, Bakos E, Needs P, Kroon P, Valentova K, Poor M, et al.
Eur J Pharm Sci
. 2024 Mar;
196:106740.
PMID: 38437885
Organic anion transporting polypeptides (OATPs), OATP1B1 and OATP2B1 are membrane proteins mediating the cellular uptake of chemically diverse organic compounds. OATP1B1 is exclusively expressed in hepatocytes and plays a key...
2.
Ozyel B, Le Gall G, Needs P, Kroon P
Mol Nutr Food Res
. 2021 Jan;
65(6):e2000777.
PMID: 33481349
Scope: Pro-inflammatory stimuli such as hyperglycemia and cytokines have been shown to negatively affect endothelial cell functions. The aim of this study is to assess the potential of quercetin and...
3.
Tung W, Rizzo B, Dabbagh Y, Saraswat S, Romanczyk M, Codorniu-Hernandez E, et al.
Arch Biochem Biophys
. 2020 Oct;
694:108589.
PMID: 33010229
There is ample evidence in the epidemiological literature that polyphenols, the major non-vitamin antioxidants in plant foods and beverages, have a beneficial effect on heart disease. Until recently other mechanisms...
4.
Anacleto S, Milenkovic D, Kroon P, Needs P, Lajolo F, Hassimotto N
Food Funct
. 2020 Sep;
11(10):8612-8624.
PMID: 32959863
Cholesterol is one of the triggers of oxidative stress in the pancreatic-β cell, generating high levels of reactive oxygen species, which leads to impairment of insulin synthesis and secretion. Bioactive...
5.
Mohos V, Fliszar-Nyul E, Ungvari O, Kuffa K, Needs P, Kroon P, et al.
Nutrients
. 2020 Aug;
12(8).
PMID: 32751996
Quercetin is a flavonoid, its glycosides and aglycone are found in significant amounts in several plants and dietary supplements. Because of the high presystemic biotransformation of quercetin, mainly its conjugates...
6.
Hollands W, Philo M, Perez-Moral N, Needs P, Savva G, Kroon P
Mol Nutr Food Res
. 2020 Mar;
64(10):e1901135.
PMID: 32223044
Scope: The majority of ingested flavanols reach the colon where they are catabolized by the microbiota to form hydroxyphenyl-γ-valerolactones (HGVLs). It is not known if the HGVLs are catabolic products...
7.
Aboufarrag H, Needs P, Rimbach G, Kroon P
Nutrients
. 2019 Nov;
11(12).
PMID: 31771252
High circulating HDL concentrations and measures of various HDL functions are inversely associated with cardiovascular disease (CVD) risk. Paraoxonase 1 (PON1) contributes to many of the athero-protective functions of HDL,...
8.
Livingstone T, Beasy G, Mills R, Plumb J, Needs P, Mithen R, et al.
Nutrients
. 2019 Sep;
11(9).
PMID: 31540470
Prostate cancer has become the most common form of non-cutaneous (internal) malignancy in men, accounting for 26% of all new male visceral cancer cases in the UK. The aetiology and...
9.
Coode-Bate J, Sivapalan T, Melchini A, Saha S, Needs P, Dainty J, et al.
Mol Nutr Food Res
. 2019 Aug;
63(20):e1900461.
PMID: 31410992
Scope: Observational studies have associated consumption of cruciferous vegetables with reduced risk of prostate cancer. This effect has been associated with the degradation products of glucosinolates-thioglycosides that accumulate within crucifers....
10.
Perez-Moral N, Needs P, Moyle C, Kroon P
Molecules
. 2019 Aug;
24(15).
PMID: 31370204
Some polyphenols have been shown to inhibit, at physiological levels, the VEGF-induced VEGF receptor-2 signaling that causes angiogenesis, allegedly by direct interaction with VEGF and reducing the binding to its...