David A Hughes
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Explore the profile of David A Hughes including associated specialties, affiliations and a list of published articles.
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88
Citations
2265
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Recent Articles
1.
Goulding N, Goudswaard L, Hughes D, Corbin L, Groom A, Ring S, et al.
Wellcome Open Res
. 2024 Sep;
7:277.
PMID: 39268475
Proteomics is the identification, detection and quantification of proteins within a biological sample. The complete set of proteins expressed by an organism is known as the proteome. The availability of...
2.
Hamilton F, Hughes D, Spiller W, Tilling K, Davey Smith G
Eur J Epidemiol
. 2024 May;
39(5):451-465.
PMID: 38789826
Mendelian randomisation (MR) is an established technique in epidemiological investigation, using the principle of random allocation of genetic variants at conception to estimate the causal linear effect of an exposure...
3.
Hughes D, Li-Gao R, Bull C, de Mutsert R, Rosendaal F, Mook-Kanamori D, et al.
Am J Clin Nutr
. 2024 Mar;
119(5):1354-1370.
PMID: 38494119
Background: Metabolite abundance is a dynamic trait that varies in response to environmental stimuli and phenotypic traits, such as food consumption and body mass index (BMI, kg/m). Objectives: In this...
4.
Constantinescu A, Hughes D, Bull C, Fleming K, Mitchell R, Zheng J, et al.
Hum Genomics
. 2024 Mar;
18(1):26.
PMID: 38491524
Background: 'Benign ethnic neutropenia' (BEN) is a heritable condition characterized by lower neutrophil counts, predominantly observed in individuals of African ancestry, and the genetic basis of BEN remains a subject...
5.
Karjalainen M, Karthikeyan S, Oliver-Williams C, Sliz E, Allara E, Fung W, et al.
Nature
. 2024 Mar;
628(8006):130-138.
PMID: 38448586
Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism. This detailed knowledge of the genetic determinants of systemic metabolism has been...
6.
Bull C, Hazelwood E, Legge D, Corbin L, Richardson T, Lee M, et al.
EBioMedicine
. 2024 Jan;
100:104977.
PMID: 38290287
Background: Type 2 diabetes is associated with higher risk of several cancer types. However, the biological intermediates driving this relationship are not fully understood. As novel interventions for treating and...
7.
Goudswaard L, Smith M, Hughes D, Taylor R, Lean M, Sattar N, et al.
Sci Rep
. 2023 Nov;
13(1):21077.
PMID: 38030643
Thousands of proteins circulate in the bloodstream; identifying those which associate with weight and intervention-induced weight loss may help explain mechanisms of diseases associated with adiposity. We aimed to identify...
8.
Corbin L, Hughes D, Bull C, Vincent E, Smith M, McConnachie A, et al.
Diabetologia
. 2023 Oct;
67(1):74-87.
PMID: 37878066
Aims/hypothesis: High-throughput metabolomics technologies in a variety of study designs have demonstrated a consistent metabolomic signature of overweight and type 2 diabetes. However, the extent to which these metabolomic patterns...
9.
Hatcher C, Richenberg G, Waterson S, Nguyen L, Joshi A, Carreras-Torres R, et al.
Sci Rep
. 2023 Jul;
13(1):12131.
PMID: 37495615
No abstract available.
10.
Hatcher C, Richenberg G, Waterson S, Nguyen L, Joshi A, Carreras-Torres R, et al.
Sci Rep
. 2023 Apr;
13(1):5968.
PMID: 37045850
The role of the human gut microbiome in colorectal cancer (CRC) is unclear as most studies on the topic are unable to discern correlation from causation. We apply two-sample Mendelian...