Paul W Finn
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Explore the profile of Paul W Finn including associated specialties, affiliations and a list of published articles.
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20
Citations
573
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Recent Articles
1.
Fernandez-Ciruelos B, Albanese M, Adhav A, Solomin V, Ritchie-Martinez A, Taverne F, et al.
Microbiol Spectr
. 2024 Jun;
12(8):e0014624.
PMID: 38917423
Importance: The discovery of novel antimicrobials is of paramount importance in tackling the imminent global health crisis of antimicrobial resistance. The discovery of novel antimicrobials with novel mechanisms of actions,...
2.
Jagdev R, Madsen T, Finn P
J Mol Model
. 2022 Dec;
29(1):22.
PMID: 36574054
The recent advances in the application of machine learning to drug discovery have made it a 'hot topic' for research, with hundreds of academic groups and companies integrating machine learning...
3.
Finn P
Methods Mol Biol
. 2019 Oct;
2076:71-84.
PMID: 31586322
Computer-Aided Drug Design has developed into a powerful suite of methods that complement experimental approaches to the identification of new pharmacologically active compounds. In particular, virtual screening has become a...
4.
Ebejer J, Finn P, Wong W, Deane C, Morris G
J Chem Inf Model
. 2019 May;
59(6):2600-2616.
PMID: 31117509
We present Ligity, a hybrid ligand-structure-based, non-superpositional method for virtual screening of large databases of small molecules. Ligity uses the relative spatial distribution of pharmacophoric interaction points (PIPs) derived from...
5.
Charlton M, Aleksis R, Saint-Leger A, Gupta A, Loza E, Ribas de Pouplana L, et al.
ACS Med Chem Lett
. 2018 Feb;
9(2):84-88.
PMID: 29456792
-Leucinyl benzenesulfonamides have been discovered as a novel class of potent inhibitors of leucyl-tRNA synthetase. The binding of inhibitors to the enzyme was measured by using isothermal titration calorimetry. This...
6.
Moll M, Finn P, Kavraki L
BMC Genomics
. 2016 Aug;
17 Suppl 4:431.
PMID: 27556159
Background: The human kinome contains many important drug targets. It is well-known that inhibitors of protein kinases bind with very different selectivity profiles. This is also the case for inhibitors...
7.
Ebejer J, Charlton M, Finn P
J Cheminform
. 2016 Jun;
8:30.
PMID: 27274770
Background: It is now widely recognized that there is an urgent need for new antibacterial drugs, with novel mechanisms of action, to combat the rise of multi-drug resistant bacteria. However,...
8.
Abuhammad A, Fullam E, Bhakta S, Russell A, Morris G, Finn P, et al.
Molecules
. 2014 Oct;
19(10):16274-90.
PMID: 25310152
Novel drugs to treat tuberculosis are required and the identification of potential targets is important. Piperidinols have been identified as potential antimycobacterial agents (MIC < 5 μg/mL), which also inhibit...
9.
Korb O, Finn P, Jones G
Expert Opin Drug Discov
. 2014 Aug;
9(10):1121-31.
PMID: 25146114
Introduction: Industrial, as well as academic, drug discovery efforts are usually supported by computational modelling techniques. Many of these techniques, such as virtual high-throughput docking, pharmacophore-based screening of conformer databases...
10.
Kher S, Penzo M, Fulle S, Finn P, Blackman M, Jirgensons A
Bioorg Med Chem Lett
. 2014 Aug;
24(18):4486-4489.
PMID: 25129616
Peptidic α-ketoamides have been developed as inhibitors of the malarial protease PfSUB1. The design of inhibitors was based on the best known endogenous PfSUB1 substrate sequence, leading to compounds with...