Paul W Barone
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Explore the profile of Paul W Barone including associated specialties, affiliations and a list of published articles.
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42
Citations
1101
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Recent Articles
1.
Srinivasan P, Canova C, Sha S, Nguyen T, Joseph J, Sangerman J, et al.
Biotechnol Bioeng
. 2024 Aug;
121(12):3694-3714.
PMID: 39176568
Recombinant adeno-associated virus (rAAV) is a commonly used in vivo gene therapy vector because of its nonpathogenicity, long-term transgene expression, broad tropism, and ability to transduce both dividing and nondividing...
2.
Destro F, Wu W, Srinivasan P, Joseph J, Bal V, Neufeld C, et al.
Biotechnol Adv
. 2024 Aug;
76:108433.
PMID: 39168354
Current processes for the production of recombinant adeno-associated virus (rAAV) are inadequate to meet the surging demand for rAAV-based gene therapies. This article reviews recent advances that hold the potential...
3.
Yang M, Keumurian F, Neufeld C, Skrip E, Duguid J, Vega-Mercado H, et al.
Adv Physiol Educ
. 2024 May;
48(4):733-741.
PMID: 38813607
Cell therapies have gained prominence as a promising therapeutic modality for treating a range of diseases. Despite the recent clinical successes of cell therapy products, very few formal training programs...
4.
Destro F, Joseph J, Srinivasan P, Kanter J, Neufeld C, Wolfrum J, et al.
Mol Ther Methods Clin Dev
. 2023 Sep;
30:122-146.
PMID: 37746245
Current manufacturing processes for recombinant adeno-associated viruses (rAAVs) have less-than-desired yields and produce significant amounts of empty capsids. The increasing demand and the high cost of goods for rAAV-based gene...
5.
Strutt J, Natarajan M, Lee E, Teo D, Sin W, Cheung K, et al.
Microbiol Spectr
. 2023 Aug;
:e0135023.
PMID: 37646508
Assuring that cell therapy products are safe before releasing them for use in patients is critical. Currently, compendial sterility testing for bacteria and fungi can take 7-14 days. The goal...
6.
Barone P, Keumurian F, Neufeld C, Koenigsberg A, Kiss R, Leung J, et al.
Biologicals
. 2023 Jan;
81:101661.
PMID: 36621353
The Consortium on Adventitious Agent Contamination in Biomanufacturing (CAACB) collected historical data from 20 biopharmaceutical industry members on their experience with the in vivo adventitious virus test, the in vitro...
7.
Koenigsberg A, Fowler V, Domike R, Brussel A, Barone P, Keumurian F, et al.
PDA J Pharm Sci Technol
. 2022 Oct;
77(2):115-132.
PMID: 36241212
Some members of MIT's Consortium on Adventitious Agent Contamination in Biomanufacturing (CAACB) previously published content on the "Quality Risk Management in the Context of Viral Contamination", which described tools, procedures,...
8.
Huang J, Cui L, Natarajan M, Barone P, Wolfrum J, Lee Y, et al.
Mol Ther Methods Clin Dev
. 2022 May;
25:410-424.
PMID: 35573051
Controlling microbial risks in cell therapy products (CTPs) is important for product safety. Here, we identified the nicotinic acid (NA) to nicotinamide (NAM) ratio as a biomarker that detects a...
9.
Katsikis G, Hwang I, Wang W, Bhat V, McIntosh N, Karim O, et al.
Nano Lett
. 2022 Feb;
22(4):1511-1517.
PMID: 35148107
Quantifying the composition of viral vectors used in vaccine development and gene therapy is critical for assessing their functionality. Adeno-associated virus (AAV) vectors, which are the most widely used viral...
10.
Large-scale cultured meat production: Trends, challenges and promising biomanufacturing technologies
Chen L, Guttieres D, Koenigsberg A, Barone P, Sinskey A, Springs S
Biomaterials
. 2021 Dec;
280:121274.
PMID: 34871881
Food systems of the future will need to face an increasingly clear reality - that a protein-rich diet is essential for good health, but traditional meat products will not suffice...