Richard D Braatz
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Explore the profile of Richard D Braatz including associated specialties, affiliations and a list of published articles.
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58
Citations
648
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Recent Articles
1.
Yadav J, Uddin S, Civati F, Ma W, Liebminger A, Teschner W, et al.
J Pharm Sci
. 2025 Feb;
114(3):1605-1614.
PMID: 39909221
This work describes the first development of high-concentration suspension formulations of human immune globulin. Colloidal-level dispersions of immune globulin were achieved by suspending a spray dried solid powder of protein...
2.
Hong S, Chattaraj K, Guo J, Trout B, Braatz R
Bioinformatics
. 2025 Jan;
41(2).
PMID: 39878910
Motivation: The accurate prediction of O-GlcNAcylation sites is crucial for understanding disease mechanisms and developing effective treatments. Previous machine learning (ML) models primarily relied on primary or secondary protein structural...
3.
Gurazada S, Kennedy H, Braatz R, Mehrman S, Polson S, Rombel I
Biotechnol Adv
. 2024 Dec;
79:108506.
PMID: 39708987
Gene therapy is poised to transition from niche to mainstream medicine, with recombinant adeno-associated virus (rAAV) as the vector of choice. However, robust, scalable, industrialized production is required to meet...
4.
Destro F, Braatz R
ACS Synth Biol
. 2024 Sep;
13(10):3173-3187.
PMID: 39315883
The design of biomanufacturing platforms based on viral transduction and/or propagation poses significant challenges at the intersection between synthetic biology and process engineering. This paper introduces vitraPro, a software toolkit...
5.
Srisuma P, Barbastathis G, Braatz R
Int J Pharm
. 2024 Sep;
665:124693.
PMID: 39277151
Lyophilization (aka freeze drying) has been shown to provide long-term stability for many crucial biotherapeutics, e.g., mRNA vaccines for COVID-19, allowing for higher storage temperature. The final stage of lyophilization,...
6.
Srinivasan P, Canova C, Sha S, Nguyen T, Joseph J, Sangerman J, et al.
Biotechnol Bioeng
. 2024 Aug;
121(12):3694-3714.
PMID: 39176568
Recombinant adeno-associated virus (rAAV) is a commonly used in vivo gene therapy vector because of its nonpathogenicity, long-term transgene expression, broad tropism, and ability to transduce both dividing and nondividing...
7.
Zhang Q, Pandit A, Liu Z, Guo Z, Muddu S, Wei Y, et al.
Light Sci Appl
. 2024 Aug;
13(1):200.
PMID: 39168972
Non-invasive characterization of powders may take one of two approaches: imaging and counting individual particles; or relying on scattered light to estimate the particle size distribution (PSD) of the ensemble....
8.
Destro F, Wu W, Srinivasan P, Joseph J, Bal V, Neufeld C, et al.
Biotechnol Adv
. 2024 Aug;
76:108433.
PMID: 39168354
Current processes for the production of recombinant adeno-associated virus (rAAV) are inadequate to meet the surging demand for rAAV-based gene therapies. This article reviews recent advances that hold the potential...
9.
Stover N, Ganko K, Braatz R
Biotechnol Bioeng
. 2024 May;
121(9):2636-2647.
PMID: 38695152
The in vitro transcription (IVT) reaction used in the production of messenger RNA vaccines and therapies remains poorly quantitatively understood. Mechanistic modeling of IVT could inform reaction design, scale-up, and...
10.
Linda Zhong-Johnson E, Dong Z, Canova C, Destro F, Canellas M, Hoffman M, et al.
J Biol Chem
. 2024 Apr;
300(4):107240.
PMID: 38579375
No abstract available.