Paul W Barone
Overview
Explore the profile of Paul W Barone including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
42
Citations
1101
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Nguyen T, Sha S, Hong M, Maloney A, Barone P, Neufeld C, et al.
Mol Ther Methods Clin Dev
. 2021 Jun;
21:642-655.
PMID: 34095346
Manufacturing of recombinant adeno-associated virus (rAAV) viral vectors remains challenging, with low yields and low full:empty capsid ratios in the harvest. To elucidate the dynamics of recombinant viral production, we...
12.
Sha S, Maloney A, Katsikis G, Nguyen T, Neufeld C, Wolfrum J, et al.
Biotechnol Adv
. 2021 May;
49:107764.
PMID: 33957276
Recombinant adeno-associated viruses (rAAVs) are among the most important vectors for in vivo gene therapies. With the rapid development of gene therapy, current rAAV manufacturing capacity faces a challenge to...
13.
Su J, Rice J, Hoffman J, Alvarado S, Bailey M, Kopp M, et al.
Biotechnol Bioeng
. 2021 Apr;
118(8):2967-2976.
PMID: 33913515
In recent years, high temperature short time (HTST) treatment technology has been increasingly adopted for medium treatment to mitigate the potential risk of viral contamination in mammalian cell culture GMP...
14.
Gimpel A, Katsikis G, Sha S, Maloney A, Hong M, Nguyen T, et al.
Mol Ther Methods Clin Dev
. 2021 Mar;
20:740-754.
PMID: 33738328
The optimization of upstream and downstream processes for production of recombinant adeno-associated virus (rAAV) with consistent quality depends on the ability to rapidly characterize critical quality attributes (CQAs). In the...
15.
Barone P, Wiebe M, Leung J, Hussein I, Keumurian F, Bouressa J, et al.
Nat Biotechnol
. 2020 Apr;
38(5):563-572.
PMID: 32341561
Recombinant protein therapeutics, vaccines, and plasma products have a long record of safety. However, the use of cell culture to produce recombinant proteins is still susceptible to contamination with viruses....
16.
Barone P, Avgerinos S, Ballard R, Brussel A, Clark P, Dowd C, et al.
PDA J Pharm Sci Technol
. 2018 Oct;
73(2):191-203.
PMID: 30361281
Appropriate segregation within manufacturing facilities is required by regulators and utilized by manufacturers to ensure that the final product has not been contaminated with (a) adventitious viruses, (b) another pre-/postviral...
17.
Herrington Jr W, Singh G, Wu D, Barone P, Hancock W, Ram R
Sci Rep
. 2018 Mar;
8(1):5089.
PMID: 29572496
The quality of therapeutic proteins such as hormones, subunit and conjugate vaccines, and antibodies is critical to the safety and efficacy of modern medicine. Identifying malformed proteins at the point-of-care...
18.
Ouyang W, Ko S, Wu D, Wang A, Barone P, Hancock W, et al.
Anal Chem
. 2016 Sep;
88(19):9669-9677.
PMID: 27624735
Therapeutic proteins (TPs) are critical in modern medicine, yet shortage of TPs in disaster situations and remote areas remains a worldwide challenge. Manufacturing and real-time release of TPs on demand...
19.
Nelson J, Kim S, Reuel N, Salem D, Bisker G, Landry M, et al.
Anal Chem
. 2015 Jul;
87(16):8186-93.
PMID: 26149633
Protein A is often used for the purification and detection of antibodies such as immunoglobulin G (IgG) because of its quadrivalent domains that bind to the Fc region of these...
20.
Zhang J, Landry M, Barone P, Kim J, Lin S, Ulissi Z, et al.
Nat Nanotechnol
. 2013 Nov;
8(12):959-68.
PMID: 24270641
Understanding molecular recognition is of fundamental importance in applications such as therapeutics, chemical catalysis and sensor design. The most common recognition motifs involve biological macromolecules such as antibodies and aptamers....