Paul S Hoffman
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Explore the profile of Paul S Hoffman including associated specialties, affiliations and a list of published articles.
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55
Citations
1314
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Recent Articles
1.
Hawsawi O, Xue W, Du T, Guo M, Yu X, Zhang M, et al.
Cell Rep Med
. 2025 Jan;
6(1):101890.
PMID: 39793570
Mitochondrial uncouplers dissipate proton gradients and deplete ATP production from oxidative phosphorylation (OXPHOS). While the growth of prostate cancer depends on OXPHOS-generated ATP, the oncogenic pathway mediated by the transcription...
2.
Gough A, Parker A, OBryan P, Whitehead T, Roy S, Garcia B, et al.
Microbiologyopen
. 2024 Aug;
13(4):e1429.
PMID: 39109824
The understanding of how central metabolism and fermentation pathways regulate antimicrobial susceptibility in the anaerobic pathogen Bacteroides fragilis is still incomplete. Our study reveals that B. fragilis encodes two iron-dependent,...
3.
Hoffman P
Br J Gastroenterol
. 2023 Jun;
2(1):138-142.
PMID: 37346897
Anaerobic microorganisms are often associated with chronic mucosal infections including periodontal disease, inflammatory bowel diseases, and recurrent colitis caused by . Management of these diseases requires a long term strategy,...
4.
Jain E, Zaenker E, Hoffman P, Warren C
Parasitol Res
. 2022 Jun;
121(8):2453-2455.
PMID: 35676563
Trichomoniasis is a sexually transmitted infection in humans caused by the protozoan Trichomonas vaginalis, the leading causative agent of vaginitis in women and urethritis in men worldwide. Metronidazole is the...
5.
Gui Q, Lyons D, Deeb J, Belvin B, Hoffman P, Lewis J
Front Oral Health
. 2022 Jan;
2:752929.
PMID: 35048063
Periodontitis is an inflammatory condition triggered by selected oral microbiota; thus treatment strategies should be aimed at reducing the abundance of the pathogenic bacteria. An obstacle to preclinical testing of...
6.
Gui Q, Hoffman P, Lewis J
J Oral Biosci
. 2020 Sep;
62(3):297.
PMID: 32950129
No abstract available.
7.
Hoffman P
Antibiotics (Basel)
. 2020 May;
9(5).
PMID: 32353943
It has been nearly 50 years since the golden age of antibiotic discovery (1945-1975) ended; yet, we still struggle to identify novel drug targets and to deliver new chemical classes...
8.
Gui Q, Ramsey K, Hoffman P, Lewis J
J Oral Biosci
. 2020 Apr;
62(2):195-204.
PMID: 32278683
Objectives: Although periodontal diseases result from overgrowth of anaerobic bacteria, the effect of a specific knockdown of anaerobes on the disease outcome has yet to be examined. We have reported...
9.
Gui Q, Hoffman P, Lewis J
J Oral Biosci
. 2019 Nov;
61(4):226-235.
PMID: 31706024
Objectives: Anaerobic bacteria are the major causative agents of periodontal disease. However, so far, targeted therapy aimed at reducing those pathogens has not been widely implemented. We have previously reported...
10.
Psonis J, Chahales P, Henderson N, Rigel N, Hoffman P, Thanassi D
J Biol Chem
. 2019 Aug;
294(39):14357-14369.
PMID: 31391254
Bacterial pathogens assemble adhesive surface structures termed pili or fimbriae to initiate and sustain infection of host tissues. Uropathogenic , the primary causative agent of urinary tract infections, expresses type...