Paul R Giacomin
Overview
Explore the profile of Paul R Giacomin including associated specialties, affiliations and a list of published articles.
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Articles
35
Citations
2144
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0
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Recent Articles
1.
Wong Y, Rosa B, Becker L, Camberis M, LeGros G, Zhan B, et al.
PLoS Negl Trop Dis
. 2025 Jan;
19(1):e0012780.
PMID: 39832284
More than 470 million people globally are infected with the hookworms Ancylostoma ceylanicum and Necator americanus, resulting in an annual loss of 2.1 to 4 million disability-adjusted-life-years. Current infection management...
2.
Kariyawasam T, Ciocchetta S, Visendi P, Soares Magalhaes R, Smith M, Giacomin P, et al.
PLoS Negl Trop Dis
. 2023 Nov;
17(11):e0011695.
PMID: 37956181
Background: Trichuris trichiura (whipworm) is one of the most prevalent soil transmitted helminths (STH) affecting 604-795 million people worldwide. Diagnostic tools that are affordable and rapid are required for detecting...
3.
Effect of experimental hookworm infection on insulin resistance in people at risk of type 2 diabetes
Pierce D, McDonald M, Merone L, Becker L, Thompson F, Lewis C, et al.
Nat Commun
. 2023 Jul;
14(1):4503.
PMID: 37495576
The reduced prevalence of insulin resistance and type 2 diabetes in countries with endemic parasitic worm infections suggests a protective role for worms against metabolic disorders, however clinical evidence has...
4.
Cobos C, Bansal P, Wilson D, Jones L, Zhao G, Field M, et al.
Front Med (Lausanne)
. 2022 Oct;
9:934852.
PMID: 36186812
A decline in the prevalence of parasites such as hookworms appears to be correlated with the rise in non-communicable inflammatory conditions in people from high- and middle-income countries. This correlation...
5.
Ryan S, Ruscher R, Johnston W, Pickering D, Kennedy M, Smith B, et al.
Proc Natl Acad Sci U S A
. 2022 Aug;
119(36):e2202795119.
PMID: 36037362
Parasitic helminth infections, while a major cause of neglected tropical disease burden, negatively correlate with the incidence of immune-mediated inflammatory diseases such as inflammatory bowel diseases (IBD). To evade expulsion,...
6.
Filbey K, Finney C, Giacomin P, Siracusa M
Front Immunol
. 2021 Apr;
12:663753.
PMID: 33815426
No abstract available.
7.
Buitrago G, Pickering D, Ruscher R, Cobos Caceres C, Jones L, Cooper M, et al.
Transl Res
. 2021 Mar;
232:88-102.
PMID: 33676036
The symbiotic relationships shared between humans and their gastrointestinal parasites present opportunities to discover novel therapies for inflammatory diseases. A prime example of this phenomenon is the interaction of humans...
8.
Douglas B, Oyesola O, Cooper M, Posey A, Tait Wojno E, Giacomin P, et al.
Annu Rev Immunol
. 2021 Mar;
39:639-665.
PMID: 33646858
Coevolutionary adaptation between humans and helminths has developed a finely tuned balance between host immunity and chronic parasitism due to immunoregulation. Given that these reciprocal forces drive selection, experimental models...
9.
Croese J, Miller G, Marquart L, Llewellyn S, Gupta R, Becker L, et al.
Clin Transl Gastroenterol
. 2021 Jan;
11(12):e00274.
PMID: 33512796
Introduction: Celiac disease is an autoimmune disorder where intestinal immunopathology arises after gluten consumption. Previous studies suggested that hookworm infection restores gluten tolerance; however, these studies were small (n =...
10.
Kupz A, Pai S, Giacomin P, Whan J, Walker R, Hammoudi P, et al.
Sci Rep
. 2020 Aug;
10(1):13115.
PMID: 32753607
Toxoplasmic encephalitis is an AIDS-defining condition. The decline of IFN-γ-producing CD4 T cells in AIDS is a major contributing factor in reactivation of quiescent Toxoplasma gondii to an actively replicating...