Roland Ruscher
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Explore the profile of Roland Ruscher including associated specialties, affiliations and a list of published articles.
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21
Citations
450
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Recent Articles
1.
Zhang J, Chaurasia P, Nguyen A, Huang Z, Nguyen T, Xu H, et al.
Sci Immunol
. 2025 Feb;
10(104):eadp5016.
PMID: 39982976
The interaction between the CD4/CD8 co-receptors and LCK (an Src family tyrosine kinase) is thought to augment T cell activation upon recognition of peptide-loaded major histocompatibility complexes (pMHCs). How this...
2.
Yeshi K, Ruscher R, Loukas A, Wangchuk P
Front Parasitol
. 2025 Jan;
1():984152.
PMID: 39816468
Parasitic helminths secrete and excrete a vast array of molecules known to help skew or suppress the host's immune response, thereby establishing a niche for sustained parasite maintenance. Indeed, the...
3.
Borup A, Sharifpour M, Rossen L, Whitehead B, Boysen A, Olesen R, et al.
J Extracell Vesicles
. 2025 Jan;
14(1):e70027.
PMID: 39815783
Parasitic helminths secrete extracellular vesicles (EVs) into their host tissues to modulate immune responses, but the underlying mechanisms are poorly understood. We demonstrate that Ascaris EVs are efficiently internalised by...
4.
Yakou M, Ghilas S, Tran K, Liao Y, Afshar-Sterle S, Kumari A, et al.
Sci Immunol
. 2023 Oct;
8(88):eadf2163.
PMID: 37801516
Intraepithelial lymphocytes (IELs), including αβ and γδ T cells (T-IELs), constantly survey and play a critical role in maintaining the gastrointestinal epithelium. We show that cytotoxic molecules important for defense...
5.
Peck Y, Pickering D, Mobli M, Liddell M, Wilson D, Ruscher R, et al.
J Biomol Struct Dyn
. 2023 Aug;
42(15):7934-7944.
PMID: 37572327
Several secreted proteins from helminths (parasitic worms) have been shown to have immunomodulatory activities. Asparaginyl-tRNA synthetases are abundantly secreted in the filarial nematode (AsnRS) and the parasitic flatworm (AsnRS), indicating...
6.
Yeshi K, Ruscher R, Miles K, Crayn D, Liddell M, Wangchuk P
Plants (Basel)
. 2022 Oct;
11(19).
PMID: 36235388
Plants have been a vital source of natural antioxidants since ancient times. Plants growing under various abiotic stress conditions often produce more defensive secondary metabolites such as phenolics, flavonoids, and...
7.
Cobos C, Bansal P, Wilson D, Jones L, Zhao G, Field M, et al.
Front Med (Lausanne)
. 2022 Oct;
9:934852.
PMID: 36186812
A decline in the prevalence of parasites such as hookworms appears to be correlated with the rise in non-communicable inflammatory conditions in people from high- and middle-income countries. This correlation...
8.
Ryan S, Ruscher R, Johnston W, Pickering D, Kennedy M, Smith B, et al.
Proc Natl Acad Sci U S A
. 2022 Aug;
119(36):e2202795119.
PMID: 36037362
Parasitic helminth infections, while a major cause of neglected tropical disease burden, negatively correlate with the incidence of immune-mediated inflammatory diseases such as inflammatory bowel diseases (IBD). To evade expulsion,...
9.
Ritmejeryte E, Ryan R, Byatt B, Peck Y, Yeshi K, Daly N, et al.
Chem Biol Interact
. 2022 Aug;
368:110124.
PMID: 36007634
Two new galloyl glucosides, galloyl-lawsoniaside A (4) and uromyrtoside (6), were isolated from the polar fraction of Uromyrtus metrosideros leaf extract along with another four previously identified phytochemicals (1, 2,...
10.
Wijeyesinghe S, Beura L, Pierson M, Stolley J, Adam O, Ruscher R, et al.
Nature
. 2021 Mar;
592(7854):457-462.
PMID: 33731934
In metazoans, specific tasks are relegated to dedicated organs that are established early in development, occupy discrete locations and typically remain fixed in size. The adult immune system arises from...