Paul R Brakeman
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Explore the profile of Paul R Brakeman including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
368
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Recent Articles
1.
Lombel R, Brakeman P, Sack B, Butani L
Adv Chronic Kidney Dis
. 2022 Sep;
29(3):308-317.
PMID: 36084977
Common causes of pediatric ESRD are distinct from those seen in the adult population. In the pediatric population, the most common are congenital anomalies of the kidney and urinary tract...
2.
Yu W, Marshall W, Metzger R, Brakeman P, Morsut L, Lim W, et al.
Cell Syst
. 2019 Sep;
9(3):221-227.
PMID: 31557453
Many metazoan organs are comprised of branching trees of epithelial tubes; how patterning occurs in these trees is a fundamental problem of development. Commonly, branch tips fill the volume of...
3.
Jayagopal A, Brakeman P, Soler P, Ferrell N, Fissell W, Kroetz D, et al.
J Pharmacol Exp Ther
. 2019 Mar;
369(3):523-530.
PMID: 30910922
Active transport by renal proximal tubules plays a significant role in drug disposition. During drug development, estimates of renal excretion are essential to dose determination. Kidney bioreactors that reproduce physiologic...
4.
Zinter M, Spicer A, Liu K, Orwoll B, Alkhouli M, Brakeman P, et al.
Pediatr Crit Care Med
. 2019 Jan;
20(4):323-331.
PMID: 30672838
Objectives: As acute kidney injury and elevated cumulative fluid balance commonly co-occur in pediatric acute respiratory distress syndrome, we aimed to identify risk factors for their development and evaluate their...
5.
Gao L, Yang Z, Hiremath C, Zimmerman S, Long B, Brakeman P, et al.
Development
. 2017 Sep;
144(19):3511-3520.
PMID: 28860115
In many types of tubules, continuity of the lumen is paramount to tubular function, yet how tubules generate lumen continuity is not known. We recently found that the F-actin-binding protein...
6.
Oates A, Benedict K, Sun K, Brakeman P, Lim J, Kim C
Pain
. 2016 Oct;
158(1):103-109.
PMID: 27749608
Evaluate laser acupuncture (LA) as an adjuvant therapy in pain management during percutaneous kidney biopsy procedure in children and adolescents. This prospective, double-blinded, randomized controlled trial enrolled patients aged 7...
7.
Wong T, Matthay K, Boscardin W, Hawkins R, Brakeman P, Dubois S
Pediatr Blood Cancer
. 2013 Apr;
60(9):1424-30.
PMID: 23613447
Background: Iodine-131-metaiodobenzylguanidine ((131)I-MIBG) provides targeted radiotherapy for children with neuroblastoma. The aim of our study was to evaluate systematically the acute effects of (131)I-MIBG on blood pressure in patients with...
8.
Yang Z, Zimmerman S, Brakeman P, Beaudoin 3rd G, Reichardt L, Marciano D
Development
. 2013 Mar;
140(8):1774-84.
PMID: 23487309
A fundamental process in biology is the de novo formation and morphogenesis of polarized tubules. Although these processes are essential for the formation of multiple metazoan organ systems, little is...
9.
Galvez-Santisteban M, Rodriguez-Fraticelli A, Bryant D, Vergarajauregui S, Yasuda T, Banon-Rodriguez I, et al.
Nat Cell Biol
. 2012 Jul;
14(8):838-49.
PMID: 22820376
The formation of epithelial tissues requires both the generation of apical-basal polarity and the coordination of this polarity between neighbouring cells to form a central lumen. During de novo lumen...
10.
Hu J, Yang L, Kammermeier P, Moore C, Brakeman P, Tu J, et al.
Nat Neurosci
. 2012 May;
15(6):836-44.
PMID: 22561452
Group I metabotropic glutamate receptors (mGluRs), including mGluR1 and mGluR5, are G protein–coupled receptors (GPCRs) that are expressed at excitatory synapses in brain and spinal cord. GPCRs are often negatively...