Paul P Gardner
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Explore the profile of Paul P Gardner including associated specialties, affiliations and a list of published articles.
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73
Citations
3853
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Recent Articles
1.
Gardner P
Bioinform Adv
. 2025 Feb;
5(1):vbaf011.
PMID: 39981110
Motivation: The development of accurate bioinformatic software tools is crucial for the effective analysis of complex biological data. This study examines the relationship between the academic department affiliations of authors...
2.
A Ghomi F, Jung J, Langridge G, Cain A, Boinett C, Abd El Ghany M, et al.
mBio
. 2024 Aug;
15(10):e0179824.
PMID: 39207104
The Enterobacteriaceae are a scientifically and medically important clade of bacteria, containing the model organism , as well as major human pathogens including and . Essential gene sets have been...
3.
Erdmann M, Gardner P, Lamont I
PLoS One
. 2023 Oct;
18(10):e0292818.
PMID: 37824582
Pseudomonas aeruginosa is an opportunistic pathogen that causes a wide range of problematic infections in individuals with predisposing conditions. Infections can be treated with colistin but some isolates are resistant...
4.
Cooper H, Krause K, Gardner P
PeerJ
. 2023 Mar;
11:e14969.
PMID: 36974140
Ribosome-targeting antibiotics comprise over half of antibiotics used in medicine, but our fundamental knowledge of their binding sites is derived primarily from ribosome structures of non-pathogenic species. These include ,...
5.
Gardner P, Paterson J, McGimpsey S, Ashari-Ghomi F, Umu S, Pawlik A, et al.
Genome Biol
. 2022 Feb;
23(1):56.
PMID: 35172880
Background: Computational biology provides software tools for testing and making inferences about biological data. In the face of increasing volumes of data, heuristic methods that trade software speed for accuracy...
6.
Bhandari B, Lim C, Remus D, Chen A, van Dolleweerd C, Gardner P
PLoS Comput Biol
. 2021 Oct;
17(10):e1009461.
PMID: 34610008
Recombinant protein production is a key process in generating proteins of interest in the pharmaceutical industry and biomedical research. However, about 50% of recombinant proteins fail to be expressed in...
7.
Smith L, Jackson S, Gardner P, Fineran P
Nat Protoc
. 2021 Aug;
16(9):4382-4418.
PMID: 34349283
We recently developed a high-throughput functional genomics approach, named 'SorTn-seq', to identify factors affecting expression of any gene of interest in bacteria. Our approach facilitates high-throughput screening of complex mutant...
8.
Sitter T, Vaughan A, Schoof M, Jackson S, Glare T, Cox M, et al.
Environ Microbiol
. 2021 May;
23(9):5289-5304.
PMID: 33989447
Some Serratia entomophila isolates have been successfully exploited in biopesticides due to their ability to cause amber disease in larvae of the Aotearoa (New Zealand) endemic pasture pest, Costelytra giveni....
9.
Buchka S, Hapfelmeier A, Gardner P, Wilson R, Boulesteix A
Genome Biol
. 2021 May;
22(1):152.
PMID: 33975646
Most research articles presenting new data analysis methods claim that "the new method performs better than existing methods," but the veracity of such statements is questionable. Our manuscript discusses and...
10.
Bhandari B, Lim C, Gardner P
Nucleic Acids Res
. 2021 Mar;
49(W1):W654-W661.
PMID: 33744969
Experiments that are planned using accurate prediction algorithms will mitigate failures in recombinant protein production. We have developed TISIGNER (https://tisigner.com) with the aim of addressing technical challenges to recombinant protein...